Abstract：
Autophagy is a lysosomal degradative pathway, which regulates the homeostasis of eukaryotic cells. This pathway can degrade misfolded or aggregated proteins, clear damaged organelles, and eliminate intracellular pathogens, including viruses, bacteria, and parasites. But, not all types of viruses are eliminated by autophagy. Flaviviruses (e.g., Yellow fever, Japanese encephalitis, Hepatitis C, Dengue, Zika, and West Nile viruses) are single-stranded and enveloped RNA viruses, and transmitted to humans primarily through the bites of arthropods, leading to severe and widespread illnesses. Like the coronavirus SARS-CoV-II, flaviviruses hijack autophagy for their infection and escape from host immune clearance. Thus, it is possible to control these viral infections by inhibiting autophagy. In this review, we summarize recent research progresses on hijacking of autophagy by flaviviruses and discuss the feasibility of antiviral therapies using autophagy inhibitors.
摘要：
自噬是一种溶酶体降解途径，调节真核细胞的稳态。该途径可以降解错误折叠或聚集的蛋白质，清除受损的细胞器，消除细胞内病原体，包括病毒,细菌,和寄生虫。但是,并非所有类型的病毒都被自噬消除。黄病毒(例如，黄热病,日本脑炎,丙型肝炎,登革热,Zika,和西尼罗河病毒）是单链和包膜RNA病毒，主要通过节肢动物的叮咬传播给人类，导致严重和广泛的疾病。就像冠状病毒SARS-CoV-II,黄病毒劫持自噬以感染并逃避宿主免疫清除。因此，有可能通过抑制自噬来控制这些病毒感染。在这次审查中,本文总结了黄病毒劫持自噬的最新研究进展，并讨论了使用自噬抑制剂进行抗病毒治疗的可行性。
