Abstract：
Corneal neovascularization (CoNV) is the second leading common cause of vision impairment worldwide and is a blinding pathological alteration brought on by ocular trauma, infection, and other factors. There are some limitations in the treatment of CoNV, hence it\'s critical to look into novel therapeutic targets. The corneal epithelial barrier, which is the initial barrier of the ocular surface, is an important structure that shields the eye from changes in the internal environment or invasion by the external environment. This study sought to collate evidence on the regulation of corneal epithelial barrier injury on the activation of vascular endothelial cells (VECs), basement membrane (BM) degradation, differentiation, migration, and proliferation of VECs, vascular maturation and stability, and other key processes in CoNV, so as to provide a novel concept for CoNV therapy targeting corneal epithelial barrier repair.
摘要：
角膜新生血管形成(CoNV)是全球视力障碍的第二大常见原因,是眼外伤引起的致盲病理改变,感染,和其他因素。CoNV的治疗有一些局限性，因此，研究新的治疗靶点至关重要。角膜上皮屏障，这是眼表的初始屏障，是保护眼睛免受内部环境变化或外部环境入侵的重要结构。本研究旨在整理有关角膜上皮屏障损伤对血管内皮细胞（VECs）活化的调节作用的证据。基底膜（BM）降解，分化,迁移,和VEC的扩散，血管成熟和稳定性，以及CoNV的其他关键流程，从而为CoNV靶向角膜上皮屏障修复治疗提供新的思路。
