METHODS: This study included patients aged ≥18 years who visited the allergy unit of our clinic between March 2018 and March 2022 and who underwent skin prick tests (SPTs) for aeroallergens. Patients were divided into two groups: those of the prepandemic and pandemic periods, depending on the visit dates.
RESULTS: In all, 7,687 patients were recruited; 5,074 individuals with negative SPT results were excluded. Among the 2,613 atopic patients, CR sensitivity was detected in 278 (10.6%). The prevalence of CR sensitivity was significantly higher in the pandemic group than in the prepandemic group (12% vs. 8.6%; p < 0.05). The frequency of asthma was higher in patients with CR sensitivity than in others (33.1% vs. 26%, p = 0.011). In addition, individuals with CR sensitivity were older than others (p = 0.001). CR sensitivity was more common in males than in females (44.2% vs. 37.7%, p = 0.034). Moreover, dog and HDM sensitivities were more common in individuals with CR sensitivity than in others (p = 0.004, p < 0.001, respectively).
CONCLUSIONS: This study reveals an increased sensitivity to CR during the pandemic and establishes an association between such sensitivity and the frequency of asthma. Variability in terms of CR sensitivity across different countries is emphasized. In addition, HDM and dog sensitivities were more common in individuals with CR sensitivity.
方法:这项研究包括年龄≥18岁的患者,他们在2018年3月至2022年3月期间访问了我们诊所的过敏单元,并接受了空气过敏原的皮肤点刺试验(SPT)。患者分为两组:流行前期和大流行期,取决于访问日期。
结果:总而言之,招募了7,687名患者;排除了5,074名SPT结果阴性的个体。在2,613名特应性患者中,CR灵敏度检测到278例(10.6%)。大流行组的CR敏感性患病率明显高于大流行组(12%vs.8.6%;p<0.05)。CR敏感性患者的哮喘频率高于其他患者(33.1%vs.26%,p=0.011)。此外,具有CR敏感性的个体年龄大于其他人(p=0.001).CR敏感性在男性比女性更常见(44.2%vs.37.7%,p=0.034)。此外,狗和HDM敏感性在具有CR敏感性的个体中比在其他个体中更常见(分别为p=0.004,p<0.001)。
结论:这项研究揭示了在大流行期间对CR的敏感性增加,并建立了这种敏感性与哮喘发生频率之间的关联。强调了不同国家在CR敏感性方面的差异。此外,HDM和狗敏感性在具有CR敏感性的个体中更常见。