Abstract：
The risk of fatal choking for people with schizophrenia and associations with antipsychotic medication are largely unknown. Therefore, we calculated the choking-related standardized mortality ratio for schizophrenia relative to the general population (SMRchoking). We also computed adjusted hazard ratios (aHR) of choking-related mortality for antipsychotics in a nationwide cohort of patients with schizophrenia (N = 59,916). SMRchoking was 20.5 (95 % confidence interval (CI)=17.1-23.9). The aHR was 1.74 (95 %CI=1.19-2.55) for strong dopamine 2-antagonists. For other antipsychotics, CIs included 1. Importantly, aHRs were particularly high for high dose categories of strong dopamine D2 receptor (D2R) antagonists. In conclusion, a schizophrenia diagnosis is associated with a 20-fold risk of death due to choking. This risk is elevated during use of strong D2R antagonist antipsychotics, particularly when prescribed in high dosages.
摘要：
精神分裂症患者致命窒息的风险以及与抗精神病药物的关联在很大程度上是未知的。因此,我们计算了精神分裂症相对于普通人群的窒息相关标准化死亡率比率(SMRchoking).我们还计算了全国精神分裂症患者队列中抗精神病药物窒息相关死亡率的校正风险比（aHR）（N=59,916）。SMRchoking为20.5（95%置信区间（CI）=17.1-23.9）。强多巴胺2-拮抗剂的aHR为1.74（95CI=1.19-2.55）。对于其他抗精神病药，CIs包括1。重要的是,对于强多巴胺D2受体（D2R）拮抗剂的高剂量类别，aHR特别高。总之,精神分裂症的诊断与窒息死亡的20倍风险相关.在使用强效D2R拮抗剂抗精神病药物期间，这种风险会升高，特别是在高剂量时。
