Abstract：
Monodisperse nanoparticles of biodegradable polyhydroxyalkanoates (PHAs) polymers, copolymers of 3-hydroxybutyrate (3HB) and 4-hydroxybutyrate (4HB), are synthesized using a membrane-assisted emulsion encapsulation and evaporation process for biomedical resorbable adhesives. The precise control over the diameter of these PHA particles, ranging from 100 nm to 8 μm, is achieved by adjusting the diameter of emulsion or the PHA concentration. Mechanical properties of the particles can be tailored based on the 3HB to 4HB ratio and molecular weight, primarily influenced by the level of crystallinity. These monodisperse PHA particles in solution serve as adhesives for hydrogel systems, specifically those based on poly(N, N-dimethylacrylamide) (PDMA). Semi-crystalline PHA nanoparticles exhibit stronger adhesion energy than their amorphous counterparts. Due to their self-adhesiveness, adhesion energy increases even when those PHA nanoparticles form multilayers between hydrogels. Furthermore, as they degrade and are resorbed into the body, the PHA nanoparticles demonstrate efficacy in in vivo wound closure, underscoring their considerable impact on biomedical applications.
摘要：
可生物降解的聚羟基链烷酸酯（PHA）聚合物的单分散纳米颗粒，3-羟基丁酸酯（3HB）和4-羟基丁酸酯（4HB）的共聚物，是使用用于生物医学可吸收粘合剂的膜辅助乳液包封和蒸发工艺合成的。对这些PHA颗粒直径的精确控制，范围从100纳米到8微米，通过调节乳液的直径或PHA浓度来实现。颗粒的机械性能可以根据3HB与4HB的比例和分子量进行调整。主要受结晶度的影响。这些溶液中的单分散PHA颗粒用作水凝胶系统的粘合剂，特别是那些基于聚(N，N-二甲基丙烯酰胺)(PDMA)。半结晶PHA纳米颗粒表现出比其无定形对应物更强的粘附能。由于它们的自粘性，即使当那些PHA纳米颗粒在水凝胶之间形成多层时,粘附能也增加。此外，当它们降解并被吸收到体内时，PHA纳米颗粒在体内伤口闭合中表现出功效，强调了它们对生物医学应用的巨大影响。
