PDF(Pubmed)
Abstract：
Bioabsorbable sutures can improve the medical functions of existing non-absorbable sutures, and may produce new medical effects, and are expected to become a new generation of medical degradable materials. In this study, the cytocompatibility of triclosan coated polyglactin910 sutures (CTS-PLGA910) was analyzed and different concentrations of sutures were prepared. The effects of sutures on the cytotoxicity and cell proliferation of HUVEC were studied by CCK-8 assay. The hemolysis, total antioxidant capacity (T-AOC) activity and nitric oxide (NO) content were investigated to improve the blood compatibility of sutures. The results showed that the hemolysis rate of CTS-PLGA910 was less than 5%. After treatment on HUVEC cells for 48 and 72 h, there was no significant change in NO content in CTS-PLGA910 groups compared with the control group, while T-AOC activity and antioxidant capacity were significantly increased in medium and high dose groups. In summary, the blood compatibility and cell compatibility were significantly improved, which provided a basis for the clinical application of sutures in the future.
摘要：
生物可吸收缝合线可以改善现有非吸收缝合线的医疗功能，并可能产生新的医疗效果，并有望成为新一代医用可降解材料。在这项研究中,分析了三氯生涂层聚冰川线910缝合线（CTS-PLGA910）的细胞相容性，并制备了不同浓度的缝合线。通过CCK-8实验研究了缝合线对HUVEC的细胞毒性和细胞增殖的影响。溶血，研究了总抗氧化能力（T-AOC）活性和一氧化氮（NO）含量，以改善缝合线的血液相容性。结果表明,CTS-PLGA910的溶血率小于5%。在HUVEC细胞上处理48和72小时后，与对照组相比,CTS-PLGA910组NO含量无显著变化,而T-AOC活性和抗氧化能力在中、高剂量组显著提高。总之,血液相容性和细胞相容性明显改善，为今后缝合线的临床应用提供了依据。
