PDF(Pubmed)
Abstract：
A recent study published in mBio by Cao et al. demonstrated that the helminth Trichinella sprialis (Ts) alleviates COVID-19-related cytokine storms in an IL-9-dependent way (Z. Cao, J. Wang, X. Liu, Y. Liu, et al., mBio 15:e00905-24, 2024, https://doi.org/10.1128/mbio.00905-24). A cytokine storm is a severe immune response characterized by the overproduction of proinflammatory cytokines, such as TNF-α and IFN-γ, leading to tissue damage and mortality in COVID-19 patients. This study indicated that IL-9 is crucial in protecting against cytokine storm syndromes associated with SARS-CoV-2 infection and proposed that anti-inflammatory molecules from Ts excretory/secretory (TsES) products could be a novel source for treating such illnesses.
摘要：
Cao等人最近发表在mBio上的一项研究。证明蠕虫旋毛虫（Ts）以IL-9依赖性方式缓解了COVID-19相关的细胞因子风暴（Z.曹,J.王，X.Liu,Y.Liu,etal.,mBio15:e00905-24,2024,https://doi.org/10.1128/mbio.00905-24)。细胞因子风暴是一种严重的免疫反应，其特征是促炎细胞因子的过度产生，如TNF-α和IFN-γ，导致COVID-19患者的组织损伤和死亡。这项研究表明，IL-9在预防与SARS-CoV-2感染相关的细胞因子风暴综合征方面至关重要，并提出来自Ts排泄/分泌（TsES）产物的抗炎分子可能是治疗此类疾病的新来源。
