PDF(Pubmed)
Abstract：
BACKGROUND: To evaluate the efficacy and safety of stromal vascular fraction (SVF), platelet rich plasma (PRP), and 1064-nm Q-switched Nd:YAG laser in reducing nanofat treated dark circles and wrinkles under the eyes.
METHODS: This study was a single-blinded randomized clinical trial conducted on patients with suborbital darkening under the eyes that randomly divided into control and case groups. In the control group, 15 patients were treated with one session of nanofat injection only, and five patients of each intervention groups received one session of nanofat+SVF injection, nanofat+PRP injection, and nanofat injection+Nd:YAG laser, respectively. Assessments methods were (1) evaluation of the degree of darkness and repair under the eyes by a blinded dermatologist based on clinical photographs, (2) investigating patient satisfaction, (3) using biometric variables for color, thickness, and density of the skin (only 3 months after the treatment), and (4) recording the possible adverse effects.
CONCLUSIONS: In terms of the extent of reduction in the intensity of darkness under the eyes, the combined treatment of nanofat injection together with SVF, PRP, and Nd:YAG laser had a much greater therapeutic effect than nanofat injection alone. In all three groups of combined treatments, patients were 100% satisfied. In terms of biometric variables, amount of changes in colorimeter, complete and dermal thickness, complete and dermal density, between the different groups was statistically significant. The use of combined treatments including nanofat with SVF injection, PRP, and 1064 Q-switched Nd:YAG laser may be more effective than nanofat alone, in reducing infraorbital dark circles and wrinkles.
METHODS: This study was a single-blinded randomized clinical trial conducted on patients with suborbital darkening under the eyes that randomly divided into control and case groups. In the control group, 15 patients were treated with one session of nanofat injection only, and five patients of each intervention groups received one session of nanofat+SVF injection, nanofat+PRP injection, and nanofat injection+Nd:YAG laser, respectively. Assessments methods were (1) evaluation of the degree of darkness and repair under the eyes by a blinded dermatologist based on clinical photographs, (2) investigating patient satisfaction, (3) using biometric variables for color, thickness, and density of the skin (only 3 months after the treatment), and (4) recording the possible adverse effects.
CONCLUSIONS: In terms of the extent of reduction in the intensity of darkness under the eyes, the combined treatment of nanofat injection together with SVF, PRP, and Nd:YAG laser had a much greater therapeutic effect than nanofat injection alone. In all three groups of combined treatments, patients were 100% satisfied. In terms of biometric variables, amount of changes in colorimeter, complete and dermal thickness, complete and dermal density, between the different groups was statistically significant. The use of combined treatments including nanofat with SVF injection, PRP, and 1064 Q-switched Nd:YAG laser may be more effective than nanofat alone, in reducing infraorbital dark circles and wrinkles.
摘要：
背景：为了评估基质血管分数（SVF）的疗效和安全性，富血小板血浆(PRP),和1064-nm调QNd：YAG激光可减少纳米脂肪处理的黑眼圈和眼睛下的皱纹。
方法：本研究是一项单盲随机临床试验，对眼眶下变黑的患者进行，随机分为对照组和病例组。在对照组中，15例患者仅接受一次纳米脂肪注射治疗，每个干预组的5名患者接受了一次nanofat+SVF注射，nanofat+PRP注射，和纳米粒子注入+Nd:YAG激光器，分别。评估方法是（1）由失明的皮肤科医生根据临床照片评估眼睛下的黑暗程度和修复，(2)调查患者满意度,(3)使用生物特征变量进行颜色，厚度,和皮肤密度（治疗后仅3个月），(4)记录可能的不良影响。
结论：在眼睛下方黑暗强度降低的程度方面，纳米脂肪注射与SVF联合治疗，PRP,Nd：YAG激光比单独注射纳米脂肪具有更大的治疗效果。在所有三组联合治疗中，患者100%满意。就生物特征变量而言，比色计的变化量，完整和真皮厚度，完整和真皮密度，不同组间差异有统计学意义。联合治疗的使用，包括纳米脂肪与SVF注射，PRP,1064调QNd:YAG激光器可能比单独的纳米粒子更有效，减少眶下黑眼圈和皱纹。
方法：本研究是一项单盲随机临床试验，对眼眶下变黑的患者进行，随机分为对照组和病例组。在对照组中，15例患者仅接受一次纳米脂肪注射治疗，每个干预组的5名患者接受了一次nanofat+SVF注射，nanofat+PRP注射，和纳米粒子注入+Nd:YAG激光器，分别。评估方法是（1）由失明的皮肤科医生根据临床照片评估眼睛下的黑暗程度和修复，(2)调查患者满意度,(3)使用生物特征变量进行颜色，厚度,和皮肤密度（治疗后仅3个月），(4)记录可能的不良影响。
结论：在眼睛下方黑暗强度降低的程度方面，纳米脂肪注射与SVF联合治疗，PRP,Nd：YAG激光比单独注射纳米脂肪具有更大的治疗效果。在所有三组联合治疗中，患者100%满意。就生物特征变量而言，比色计的变化量，完整和真皮厚度，完整和真皮密度，不同组间差异有统计学意义。联合治疗的使用，包括纳米脂肪与SVF注射，PRP,1064调QNd:YAG激光器可能比单独的纳米粒子更有效，减少眶下黑眼圈和皱纹。
