Abstract：
The synthesis of 5-(halomethyl)furfurals (XMFs, X = F, Cl, Br, I), including 5-(chloromethyl)furfural (CMF), 5-(bromomethyl)furfural (BMF), 5-(iodomethyl)furfural (IMF), and 5-(fluoromethyl)furfural (FMF), from biomass represents a pivotal advancement in renewable chemistry and engineering. Harnessing waste biomass as a raw material offers a sustainable alternative to fossil-based resources, mitigating environmental degradation and addressing pressing energy needs. CMF and BMF, characterized by their enhanced stability over the hydroxyl analog, 5-(hydroxymethyl)furfural (HMF), exhibit promise as renewable building blocks for scale-up and commercialization. The surge in research interest, particularly from 2010 to 2024, reflects a growing recognition of XMFs\' potential as novel platform chemicals. This review highlights the evolution of XMF synthesis methods, focusing on their transformation from saccharides and lignocellulosic biomass. Mechanistic insights and experimental setups are scrutinized for industrial feasibility and scalability, shedding light on technical challenges and avenues for further research. The analysis underscores the burgeoning significance of XMFs in the transition towards sustainable chemical production, emphasizing the importance of process optimization and mechanistic understanding for commercial deployment.
摘要：
5-（卤代甲基）糠醛（XMFs，X=F,Cl,Br,I),包括5-(氯甲基)糠醛(CMF)，5-（溴甲基）糠醛（BMF），5-（碘甲基）糠醛（IMF），和5-(氟甲基)糠醛(FMF)，生物质代表了可再生化学和工程的关键进步。利用废弃生物质作为原材料为化石资源提供了可持续的替代方案，缓解环境退化和解决紧迫的能源需求。CMF和BMF,其特征在于它们比羟基类似物具有增强的稳定性，5-（羟甲基）糠醛（HMF），展示作为扩大规模和商业化的可再生基石的承诺。研究兴趣的激增，特别是从2010年到2024年，反映出人们越来越认识到XMFs作为新型平台化学品的潜力。这篇综述重点介绍了XMF合成方法的演变，专注于它们从糖类和木质纤维素生物质的转化。对机械见解和实验设置进行了审查，以了解工业可行性和可扩展性，阐明技术挑战和进一步研究的途径。分析强调了XMF在向可持续化学生产过渡中的新兴意义，强调流程优化和机械理解对商业部署的重要性。
