PDF(Pubmed)
Abstract：
BACKGROUND: Vitamin deficiencies are linked to various eye diseases, and the influence of vitamin D on cataract formation has been noted in prior research. However, detailed investigations into the causal relationship between 25-(OH)D status and cataract development remain scarce.
OBJECTIVE: To explore a possible causal link between cataracts and vitamin D.
METHODS: In this study, we explored the causal link between 25-(OH)D levels and cataract development using Mendelian randomization. Our analytical approach included inverse-variance weighting (IVW), MR-Egger, weighted median, simple mode, and weighted mode methods. The primary analyses utilized IVW with random effects, supplemented by sensitivity and heterogeneity tests using both IVW and MR-Egger. MR-Egger was also applied for pleiotropy testing. Additionally, a leave-one-out analysis helped identify potentially impactful single-nucleotide polymorphisms.
RESULTS: The analysis revealed a positive association between 25-(OH)D levels and the risk of developing cataracts (OR = 1.11, 95%CI: 1.00-1.22; P = 0.032). The heterogeneity test revealed that our IVW analysis exhibited minimal heterogeneity (P > 0.05), and the pleiotropy test findings confirmed the absence of pleiotropy within our IVW analysis (P > 0.05). Furthermore, a search of the human genotype-phenotype association database failed to identify any potentially relevant risk-factor single nucleotide polymorphisms.
CONCLUSIONS: There is a potential causal link between 25-(OH)D levels and the development of cataracts, suggesting that greater 25-(OH)D levels may be a contributing risk factor for cataract formation. Further experimental research is required to confirm these findings.
OBJECTIVE: To explore a possible causal link between cataracts and vitamin D.
METHODS: In this study, we explored the causal link between 25-(OH)D levels and cataract development using Mendelian randomization. Our analytical approach included inverse-variance weighting (IVW), MR-Egger, weighted median, simple mode, and weighted mode methods. The primary analyses utilized IVW with random effects, supplemented by sensitivity and heterogeneity tests using both IVW and MR-Egger. MR-Egger was also applied for pleiotropy testing. Additionally, a leave-one-out analysis helped identify potentially impactful single-nucleotide polymorphisms.
RESULTS: The analysis revealed a positive association between 25-(OH)D levels and the risk of developing cataracts (OR = 1.11, 95%CI: 1.00-1.22; P = 0.032). The heterogeneity test revealed that our IVW analysis exhibited minimal heterogeneity (P > 0.05), and the pleiotropy test findings confirmed the absence of pleiotropy within our IVW analysis (P > 0.05). Furthermore, a search of the human genotype-phenotype association database failed to identify any potentially relevant risk-factor single nucleotide polymorphisms.
CONCLUSIONS: There is a potential causal link between 25-(OH)D levels and the development of cataracts, suggesting that greater 25-(OH)D levels may be a contributing risk factor for cataract formation. Further experimental research is required to confirm these findings.
摘要：
背景：维生素缺乏与各种眼部疾病有关，维生素D对白内障形成的影响在先前的研究中已经注意到。然而,对25-（OH）D状态与白内障发展之间因果关系的详细研究仍然很少。
目的：探讨白内障与维生素D之间可能的因果关系。
方法：在本研究中，我们采用孟德尔随机化法探讨了25-(OH)D水平与白内障发生之间的因果关系.我们的分析方法包括方差逆加权(IVW)，MR-Egger,加权中位数，简单模式，和加权模式方法。主要分析利用具有随机效应的IVW，辅以IVW和MR-Egger的敏感性和异质性测试。MR-Egger也用于多效性测试。此外,留一法分析有助于确定可能有影响的单核苷酸多态性.
结果：分析显示25-(OH)D水平与白内障发病风险呈正相关(OR=1.11,95CI:1.00-1.22;P=0.032)。异质性检验显示我们的IVW分析表现出最小的异质性(P>0.05)。多效性检验结果证实我们的IVW分析中不存在多效性(P>0.05)。此外，对人类基因型-表型关联数据库的搜索未能确定任何潜在相关的危险因素单核苷酸多态性.
结论：25-（OH）D水平与白内障的发展之间存在潜在的因果关系，提示较高的25-(OH)D水平可能是白内障形成的危险因素。需要进一步的实验研究来证实这些发现。
目的：探讨白内障与维生素D之间可能的因果关系。
方法：在本研究中，我们采用孟德尔随机化法探讨了25-(OH)D水平与白内障发生之间的因果关系.我们的分析方法包括方差逆加权(IVW)，MR-Egger,加权中位数，简单模式，和加权模式方法。主要分析利用具有随机效应的IVW，辅以IVW和MR-Egger的敏感性和异质性测试。MR-Egger也用于多效性测试。此外,留一法分析有助于确定可能有影响的单核苷酸多态性.
结果：分析显示25-(OH)D水平与白内障发病风险呈正相关(OR=1.11,95CI:1.00-1.22;P=0.032)。异质性检验显示我们的IVW分析表现出最小的异质性(P>0.05)。多效性检验结果证实我们的IVW分析中不存在多效性(P>0.05)。此外，对人类基因型-表型关联数据库的搜索未能确定任何潜在相关的危险因素单核苷酸多态性.
结论：25-（OH）D水平与白内障的发展之间存在潜在的因果关系，提示较高的25-(OH)D水平可能是白内障形成的危险因素。需要进一步的实验研究来证实这些发现。
