PDF(Pubmed)
Abstract：
Malaria remains a significant global health challenge, with Plasmodium parasites transmitted by Anopheles mosquitoes causing substantial morbidity and mortality. Despite historical efforts, malaria continues to affect millions worldwide, particularly in tropical regions. This systematic review aimed to assess the acceptability of the RTS, S/AS01 malaria vaccine among diverse populations. A comprehensive search strategy was employed across databases such as Cochrane Library, Embase, Google Scholar, and Medline. Studies were included based on specific criteria, including observational and cross-sectional designs involving adults. Data extraction and analysis were conducted meticulously, encompassing key variables related to vaccine acceptance rates and influencing factors. Analysis of 18 studies involving 18,561 participants revealed an overall malaria vaccine acceptance rate of 87.51%, ranging from 32.26% to 99.30%. Significant variations were observed based on demographics, with Ghana and Nigeria reporting high acceptance rates. Factors influencing acceptance included knowledge levels, past vaccination experiences, community preferences, and engagement in malaria prevention behaviors. Concerns about adverse reactions and regional disparities were noted as potential barriers to acceptance. This review highlights the importance of understanding public perceptions and concerns regarding malaria vaccines to enhance vaccine coverage and uptake. Tailored communication strategies, advocacy efforts, and targeted education interventions are crucial for addressing misconceptions and increasing vaccine acceptance. Policy recommendations should consider demographic and regional factors to ensure effective implementation of malaria vaccination programs, ultimately contributing to global malaria prevention efforts and public health initiatives.
摘要：
疟疾仍然是一个重大的全球卫生挑战，疟原虫寄生虫由按蚊传播，导致大量发病率和死亡率。尽管历史的努力，疟疾继续影响着全世界数百万人，特别是在热带地区。本系统综述旨在评估RTS的可接受性，不同人群的S/AS01疟疾疫苗。在CochraneLibrary等数据库中采用了全面的搜索策略，Embase,谷歌学者，Medline根据具体标准纳入研究，包括成人的观察性和横断面设计。对数据进行了细致的提取和分析,涵盖与疫苗接受率和影响因素相关的关键变量。对涉及18,561名参与者的18项研究的分析显示，疟疾疫苗的总体接受率为87.51％，从32.26%到99.30%不等。根据人口统计学观察到显著的变化，加纳和尼日利亚报告接受率很高。影响接受的因素包括知识水平，过去的疫苗接种经验，社区偏好,参与疟疾预防行为。有人指出，对不良反应和区域差异的担忧是接受的潜在障碍。这篇综述强调了了解公众对疟疾疫苗的看法和关注以提高疫苗覆盖率和吸收的重要性。量身定制的沟通策略，宣传努力，和有针对性的教育干预措施对于消除误解和提高疫苗接受度至关重要。政策建议应考虑人口和区域因素，以确保有效实施疟疾疫苗接种计划，最终为全球疟疾预防工作和公共卫生举措做出贡献。
