PDF(Pubmed)
Abstract：
BACKGROUND: Diabetic foot ulcers (DFUs) are a common complication of diabetes, often leading to severe infections, amputations, and reduced quality of life. The current standard treatment protocols for DFUs have limitations in promoting efficient wound healing and preventing complications. A comprehensive treatment approach targeting multiple aspects of wound care may offer improved outcomes for patients with DFUs. The hypothesis of this study is that a comprehensive treatment protocol for DFUs will result in faster wound healing, reduced amputation rates, and improved overall patient outcomes compared to standard treatment protocols.
OBJECTIVE: To compare the efficacy and safety of a comprehensive treatment protocol for DFUs with those of the standard treatment protocol.
METHODS: This retrospective study included 62 patients with DFUs, enrolled between January 2022 and January 2024, randomly assigned to the experimental (n = 32) or control (n = 30) group. The experimental group received a comprehensive treatment comprising blood circulation improvement, debridement, vacuum sealing drainage, recombinant human epidermal growth factor and anti-inflammatory dressing, and skin grafting. The control group received standard treatment, which included wound cleaning and dressing, antibiotics administration, and surgical debridement or amputation, if necessary. Time taken to reduce the white blood cell count, number of dressing changes, wound healing rate and time, and amputation rate were assessed.
RESULTS: The experimental group exhibited significantly better outcomes than those of the control group in terms of the wound healing rate, wound healing time, and amputation rate. Additionally, the comprehensive treatment protocol was safe and well tolerated by the patients.
CONCLUSIONS: Comprehensive treatment for DFUs is more effective than standard treatment, promoting granulation tissue growth, shortening hospitalization time, reducing pain and amputation rate, improving wound healing, and enhancing quality of life.
OBJECTIVE: To compare the efficacy and safety of a comprehensive treatment protocol for DFUs with those of the standard treatment protocol.
METHODS: This retrospective study included 62 patients with DFUs, enrolled between January 2022 and January 2024, randomly assigned to the experimental (n = 32) or control (n = 30) group. The experimental group received a comprehensive treatment comprising blood circulation improvement, debridement, vacuum sealing drainage, recombinant human epidermal growth factor and anti-inflammatory dressing, and skin grafting. The control group received standard treatment, which included wound cleaning and dressing, antibiotics administration, and surgical debridement or amputation, if necessary. Time taken to reduce the white blood cell count, number of dressing changes, wound healing rate and time, and amputation rate were assessed.
RESULTS: The experimental group exhibited significantly better outcomes than those of the control group in terms of the wound healing rate, wound healing time, and amputation rate. Additionally, the comprehensive treatment protocol was safe and well tolerated by the patients.
CONCLUSIONS: Comprehensive treatment for DFUs is more effective than standard treatment, promoting granulation tissue growth, shortening hospitalization time, reducing pain and amputation rate, improving wound healing, and enhancing quality of life.
摘要：
背景：糖尿病足溃疡（DFU）是糖尿病的常见并发症，经常导致严重的感染，截肢,降低了生活质量。目前DFU的标准治疗方案在促进有效伤口愈合和预防并发症方面具有局限性。针对伤口护理的多个方面的综合治疗方法可以为DFU患者提供改善的结果。这项研究的假设是，DFU的综合治疗方案将导致更快的伤口愈合，降低截肢率，与标准治疗方案相比，改善了患者的总体结局。
目的：比较DFU综合治疗方案与标准治疗方案的疗效和安全性。
方法：这项回顾性研究包括62例DFU患者，在2022年1月至2024年1月之间招募，随机分配到实验组（n=32）或对照组（n=30）。实验组接受包括改善血液循环在内的综合治疗，清创术,真空密封引流,重组人表皮生长因子和抗炎敷料，和植皮。对照组接受标准治疗,其中包括伤口清洁和敷料，抗生素管理，手术清创或截肢，如有必要。减少白细胞计数所需的时间，换药次数,伤口愈合率和时间，并评估截肢率。
结果：试验组在创面愈合率方面明显优于对照组，伤口愈合时间,截肢率。此外,综合治疗方案安全,患者耐受性良好.
结论：DFU的综合治疗比标准治疗更有效，促进肉芽组织生长，缩短住院时间，减少疼痛和截肢率，改善伤口愈合，提高生活质量。
目的：比较DFU综合治疗方案与标准治疗方案的疗效和安全性。
方法：这项回顾性研究包括62例DFU患者，在2022年1月至2024年1月之间招募，随机分配到实验组（n=32）或对照组（n=30）。实验组接受包括改善血液循环在内的综合治疗，清创术,真空密封引流,重组人表皮生长因子和抗炎敷料，和植皮。对照组接受标准治疗,其中包括伤口清洁和敷料，抗生素管理，手术清创或截肢，如有必要。减少白细胞计数所需的时间，换药次数,伤口愈合率和时间，并评估截肢率。
结果：试验组在创面愈合率方面明显优于对照组，伤口愈合时间,截肢率。此外,综合治疗方案安全,患者耐受性良好.
结论：DFU的综合治疗比标准治疗更有效，促进肉芽组织生长，缩短住院时间，减少疼痛和截肢率，改善伤口愈合，提高生活质量。
