PDF(Pubmed)
Abstract：
Alcohol consumption occurring in a social or solitary setting often yields different behavioural responses in human subjects. For example, social drinking is associated with positive effects while solitary drinking is linked to negative effects. However, the neurobiological mechanism by which the social environment during alcohol intake impacts on behavioural responses remains poorly understood. We investigated whether distinct social environments affect behavioural responses to ethanol and the role of the dopamine system in this phenomenon in the fruit fly Drosophila melanogaster. The wild-type Canton-S (CS) flies showed higher locomotor response when exposed to ethanol in a group setting than a solitary setting, and there was no difference in females and males. Dopamine signalling is crucial for the locomotor stimulating effect of ethanol. When subjected to ethanol exposure alone, the dopamine transport mutant flies fumin (fmn) with hyper dopamine displayed the locomotor response similar to CS. When subjected to ethanol in a group setting, however, the fmn\'s response to the locomotor stimulating effect was substantially augmented compared with CS, indicating synergistic interaction of dopamine signalling and social setting. To identify the dopamine signalling pathway important for the social effect, we examined the flies defective in individual dopamine receptors and found that the D1 receptor dDA1/Dop1R1 is the major receptor mediating the social effect. Taken together, this study underscores the influence of social context on the neural and behavioural responses to ethanol.
摘要：
在社交或孤独环境中发生的酒精消费通常会在人类受试者中产生不同的行为反应。例如,社交饮酒与积极影响相关，而单独饮酒与负面影响相关。然而,饮酒期间社会环境对行为反应的神经生物学机制仍然知之甚少。我们调查了不同的社会环境是否会影响果蝇果蝇对乙醇的行为反应以及多巴胺系统在这种现象中的作用。在一组环境中暴露于乙醇时，野生型Canton-S（CS）果蝇表现出比单独环境更高的运动反应，女性和男性没有差异。多巴胺信号传导对于乙醇的运动刺激作用至关重要。当单独暴露于乙醇时，多巴胺转运突变体果蝇fumin（fmn）与高多巴胺表现出类似于CS的运动反应。当在一组环境中接受乙醇时，然而,与CS相比，fmn对运动刺激作用的反应显着增强，表明多巴胺信号和社会环境的协同相互作用。为了识别对社会效应重要的多巴胺信号通路，我们检查了果蝇的单个多巴胺受体缺陷，发现D1受体dDA1/Dop1R1是介导社会效应的主要受体。一起来看,这项研究强调了社会环境对乙醇的神经和行为反应的影响。
