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Abstract：
BACKGROUND: Alzheimer\'s disease and related dementias (ADRD) and Parkinson\'s disease (PD), pose growing global health challenges. Socio-demographic and economic development acts paradoxically, complicating the process that determines how governments worldwide designate policies and allocate resources for healthcare.
METHODS: We extracted data on ADRD and PD in 204 countries from the Global Burden of Disease 2019 database. Health disparities were estimated using the slope index of inequality (SII), and concentration index (CIX) based on the socio-demographic index. Estimated annual percentage changes (EAPCs) were employed to evaluate temporal trends.
RESULTS: Globally, the SII increased from 255.4 [95% confidence interval (CI), 215.2 to 295.5)] in 1990 to 559.3 (95% CI, 497.2 to 621.3) in 2019 for ADRD, and grew from 66.0 (95% CI, 54.9 to 77.2) in 1990 to 132.5 (95% CI, 118.1 to 147.0) in 2019 for PD; CIX rose from 33.7 (95% CI, 25.8 to 41.6) in 1990 to 36.9 (95% CI, 27.8 to 46.1) in 2019 for ADRD, and expanded from 22.2 (95% CI, 21.3 to 23.0) in 1990 to 29.0 (95% CI, 27.8 to 30.3) in 2019 for PD. Age-standardized disability-adjusted life years displayed considerable upward trends for ADRD [EAPC = 0.43 (95% CI, 0.27 to 0.59)] and PD [0.34 (95% CI, 0.29 to 0.38)].
CONCLUSIONS: Globally, the burden of ADRD and PD continues to increase with growing health disparities. Variations in health inequalities and the impact of socioeconomic development on disease trends underscored the need for targeted policies and strategies, with heightened awareness, preventive measures, and active management of risk factors.
METHODS: We extracted data on ADRD and PD in 204 countries from the Global Burden of Disease 2019 database. Health disparities were estimated using the slope index of inequality (SII), and concentration index (CIX) based on the socio-demographic index. Estimated annual percentage changes (EAPCs) were employed to evaluate temporal trends.
RESULTS: Globally, the SII increased from 255.4 [95% confidence interval (CI), 215.2 to 295.5)] in 1990 to 559.3 (95% CI, 497.2 to 621.3) in 2019 for ADRD, and grew from 66.0 (95% CI, 54.9 to 77.2) in 1990 to 132.5 (95% CI, 118.1 to 147.0) in 2019 for PD; CIX rose from 33.7 (95% CI, 25.8 to 41.6) in 1990 to 36.9 (95% CI, 27.8 to 46.1) in 2019 for ADRD, and expanded from 22.2 (95% CI, 21.3 to 23.0) in 1990 to 29.0 (95% CI, 27.8 to 30.3) in 2019 for PD. Age-standardized disability-adjusted life years displayed considerable upward trends for ADRD [EAPC = 0.43 (95% CI, 0.27 to 0.59)] and PD [0.34 (95% CI, 0.29 to 0.38)].
CONCLUSIONS: Globally, the burden of ADRD and PD continues to increase with growing health disparities. Variations in health inequalities and the impact of socioeconomic development on disease trends underscored the need for targeted policies and strategies, with heightened awareness, preventive measures, and active management of risk factors.
摘要：
背景：阿尔茨海默病和相关痴呆（ADRD）和帕金森病（PD），带来日益严重的全球卫生挑战。社会人口和经济发展行为自相矛盾，使决定全球政府如何为医疗保健指定政策和分配资源的过程变得复杂。
方法：我们从全球疾病负担2019数据库中提取了204个国家的ADRD和PD数据。使用不平等斜率指数(SII)估计健康差异，和基于社会人口指数的集中指数(CIX)。估计的年度百分比变化(EAPC)被用来评估时间趋势。
结果：全球，SII从255.4增加[95%置信区间(CI)，215.2至295.5）]1990年至2019年ADRD的559.3（95%CI，497.2至621.3），PD从1990年的66.0（95％CI，54.9至77.2）增长到2019年的132.5（95％CI，118.1至147.0）；ADRD的CIX从1990年的33.7（95％CI，25.8至41.6）上升到2019年的36.9（95％CI，27.8至46.1），PD从1990年的22.2（95%CI，21.3至23.0）扩大到2019年的29.0（95%CI，27.8至30.3）。年龄标准化的残疾调整寿命年显示ADRD[EAPC=0.43（95％CI，0.27至0.59）]和PD[0.34（95％CI，0.29至0.38）]有相当大的上升趋势。
结论：全球，随着健康差距的扩大，ADRD和PD的负担继续增加。卫生不平等的变化以及社会经济发展对疾病趋势的影响强调了需要有针对性的政策和战略，随着意识的提高，预防措施,积极管理风险因素。
方法：我们从全球疾病负担2019数据库中提取了204个国家的ADRD和PD数据。使用不平等斜率指数(SII)估计健康差异，和基于社会人口指数的集中指数(CIX)。估计的年度百分比变化(EAPC)被用来评估时间趋势。
结果：全球，SII从255.4增加[95%置信区间(CI)，215.2至295.5）]1990年至2019年ADRD的559.3（95%CI，497.2至621.3），PD从1990年的66.0（95％CI，54.9至77.2）增长到2019年的132.5（95％CI，118.1至147.0）；ADRD的CIX从1990年的33.7（95％CI，25.8至41.6）上升到2019年的36.9（95％CI，27.8至46.1），PD从1990年的22.2（95%CI，21.3至23.0）扩大到2019年的29.0（95%CI，27.8至30.3）。年龄标准化的残疾调整寿命年显示ADRD[EAPC=0.43（95％CI，0.27至0.59）]和PD[0.34（95％CI，0.29至0.38）]有相当大的上升趋势。
结论：全球，随着健康差距的扩大，ADRD和PD的负担继续增加。卫生不平等的变化以及社会经济发展对疾病趋势的影响强调了需要有针对性的政策和战略，随着意识的提高，预防措施,积极管理风险因素。
