PDF(Pubmed)
Abstract：
OBJECTIVE: The visibility of biopsy needles in contrast-specific imaging mode can be improved by priming them with an ultrasound contrast agent (previously demonstrated in a phantom model/ex vivo). The purpose of this study was to validate this priming method in a porcine in vivo model.
METHODS: Using a small syringe, full-core biopsy needles were primed with sulfur hexafluoride, an ultrasound contrast agent, with non-primed needles serving as controls (n = 30 + 30). Liver punctures were performed in a porcine model following intravenous administration of the same ultrasound contrast agent. Needle visibility, both in their entirety and at the tips, was evaluated in split-screen mode using contrast-specific imaging and B-mode (low mechanical index). The assessment included quantitative analysis, calculating the contrast-to-noise ratio, and qualitative evaluation through structured grading by three radiologists.
RESULTS: After needle priming, the contrast-to-noise ratio was superior for the needle in its entirety in contrast-specific imaging mode (p < 0.001) and slightly inferior in B-mode (p = 0.008). No differences were observed for the needle tips in either imaging mode. Qualitatively, the needle visibility was deemed clinically superior after needle priming throughout in contrast-specific imaging mode (p < 0.001), whereas no clinically relevant differences in B-mode for either the needle in its entirety (p = 0.11) or the needle tip (p = 1) were observed.
CONCLUSIONS: In this in vivo porcine liver model experiment, priming biopsy needles with ultrasound contrast agent improved needle visibility in contrast-specific imaging mode but slightly reduced it in B-mode. These findings support the method\'s use for biopsies requiring target visualization in contrast-specific imaging mode.
METHODS:
METHODS: Using a small syringe, full-core biopsy needles were primed with sulfur hexafluoride, an ultrasound contrast agent, with non-primed needles serving as controls (n = 30 + 30). Liver punctures were performed in a porcine model following intravenous administration of the same ultrasound contrast agent. Needle visibility, both in their entirety and at the tips, was evaluated in split-screen mode using contrast-specific imaging and B-mode (low mechanical index). The assessment included quantitative analysis, calculating the contrast-to-noise ratio, and qualitative evaluation through structured grading by three radiologists.
RESULTS: After needle priming, the contrast-to-noise ratio was superior for the needle in its entirety in contrast-specific imaging mode (p < 0.001) and slightly inferior in B-mode (p = 0.008). No differences were observed for the needle tips in either imaging mode. Qualitatively, the needle visibility was deemed clinically superior after needle priming throughout in contrast-specific imaging mode (p < 0.001), whereas no clinically relevant differences in B-mode for either the needle in its entirety (p = 0.11) or the needle tip (p = 1) were observed.
CONCLUSIONS: In this in vivo porcine liver model experiment, priming biopsy needles with ultrasound contrast agent improved needle visibility in contrast-specific imaging mode but slightly reduced it in B-mode. These findings support the method\'s use for biopsies requiring target visualization in contrast-specific imaging mode.
METHODS:
摘要：
目的：可以通过用超声造影剂（先前在体模模型/离体中证明）对活检针在造影剂特异性成像模式下的可见性来提高活检针的可见性。这项研究的目的是在猪体内模型中验证这种引发方法。
方法：使用小注射器，全核心活检针用六氟化硫灌注，超声造影剂,用非灌注针头作为对照（n=30+30）。在静脉内施用相同超声造影剂后,在猪模型中进行肝穿刺。针头可见性,无论是在整体上还是在提示上，使用对比度特异性成像和B模式（低机械指数）在分屏模式下进行评估。评估包括定量分析，计算对比度噪声比，并通过三位放射科医生的结构化分级进行定性评估。
结果：打针后，在对比剂特定成像模式下,整个针头的对比噪声比更优(p<0.001),在B模式下稍差(p=0.008).在任一成像模式下,对于针尖均未观察到差异。定性,在对比剂特定成像模式下，针灌注后，针的可见性被认为是临床上更好的（p<0.001），而对于整个针头（p=0.11）或针尖（p=1），均未观察到B型的临床相关差异。
结论：在此体内猪肝模型实验中，用超声造影剂启动活检针可在造影剂特定成像模式下提高针的可见度，但在B模式下略有降低。这些发现支持该方法用于需要在造影剂特定成像模式下进行目标可视化的活检。
方法：
方法：使用小注射器，全核心活检针用六氟化硫灌注，超声造影剂,用非灌注针头作为对照（n=30+30）。在静脉内施用相同超声造影剂后,在猪模型中进行肝穿刺。针头可见性,无论是在整体上还是在提示上，使用对比度特异性成像和B模式（低机械指数）在分屏模式下进行评估。评估包括定量分析，计算对比度噪声比，并通过三位放射科医生的结构化分级进行定性评估。
结果：打针后，在对比剂特定成像模式下,整个针头的对比噪声比更优(p<0.001),在B模式下稍差(p=0.008).在任一成像模式下,对于针尖均未观察到差异。定性,在对比剂特定成像模式下，针灌注后，针的可见性被认为是临床上更好的（p<0.001），而对于整个针头（p=0.11）或针尖（p=1），均未观察到B型的临床相关差异。
结论：在此体内猪肝模型实验中，用超声造影剂启动活检针可在造影剂特定成像模式下提高针的可见度，但在B模式下略有降低。这些发现支持该方法用于需要在造影剂特定成像模式下进行目标可视化的活检。
方法：
