Abstract：
Prebiotics may influence the risk of hormone-related female cancers by modulating the gut microbiota involved in estrogens metabolism. We evaluated the association of fiber-type prebiotic intake with breast, endometrial, and ovarian cancers. Data derived from a network of Italian hospital-based case-control studies (1991-2006), including 2560 cases of cancer of the breast (2588 controls), 454 of the endometrium (908 controls) and 1031 of the ovary (2411 controls). Inulin-type fructans (ITFs), and selected fructo-oligosaccharides (FOSs, nystose, kestose and 1F-β-fructofuranosylnystose) and galacto-oligosaccharides (GOSs, raffinose and stachyose) were quantified in food products. Prebiotic intake was estimated by multiplying food frequency questionnaire intake by the foods\' prebiotic content. Odds ratios (OR) and the corresponding 95% confidence intervals (CI) were derived by multiple logistic regression models. Nystose intake was marginally directly associated with breast (OR for the 4th versus the 1st quartile 1.20, 95% CI: 1.00-1.45), ovarian (OR 1.39, 95% CI: 1.04-1.84) and endometrial cancer risk (OR 1.32, 95% CI: 0.85-2.03). High 1F-β-fructofuranosylnystose intake was inversely associated with ovarian cancer (OR 0.67, 95% CI: 0.52-0.85). ITFs, kestose, raffinose and stachyose were not associated with the three cancers. The intake of most fiber-type prebiotics was not appreciably and consistently associated with breast, endometrial and ovarian cancer risks.
摘要：
益生元可能通过调节参与雌激素代谢的肠道微生物群来影响激素相关女性癌症的风险。我们评估了纤维型益生元摄入量与乳房的关系，子宫内膜,和卵巢癌。数据来自意大利基于医院的病例对照研究网络(1991-2006年)，包括2560例乳腺癌（2588例对照），子宫内膜454(908对照)和卵巢1031(2411对照)。菊粉型果聚糖（ITF），和选定的低聚果糖(FOSs，牡蛎,红藻糖和1F-β-呋喃果糖糖)和低聚半乳糖(GOSs，棉子糖和水苏糖）在食品中进行了定量。通过将食物频率问卷摄入量乘以食物益生元含量来估计益生元摄入量。通过多元逻辑回归模型得出赔率（OR）和相应的95％置信区间（CI）。受精卵摄入量与乳房略有直接相关（第4四分位数与第1四分位数的OR为1.20，95％CI：1.00-1.45），卵巢（OR1.39，95％CI：1.04-1.84）和子宫内膜癌风险（OR1.32，95％CI：0.85-2.03）。高1F-β-呋喃果糖糖摄入与卵巢癌呈负相关(OR0.67,95%CI:0.52-0.85)。ITF,Kestose,棉子糖和水苏糖与这三种癌症无关。大多数纤维型益生元的摄入量与乳房没有明显和一致的关系，子宫内膜癌和卵巢癌的风险。
