Abstract：
Pregnant people and their fetuses are vulnerable to adverse health outcomes from coronavirus 2019 disease (COVID-19) due to infection with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). COVID-19 has been associated with higher rates of maternal mortality, preterm birth, and stillbirth. While SARS-CoV-2 infection of the placenta and vertical transmission is rare, this may be due to the typically longer time interval between maternal infection and testing of the placenta and neonate. Placental injury is evident in cases of SARS-CoV-2-associated stillbirth with massive perivillous fibrin deposition, chronic histiocytic intervillositis, and trophoblast necrosis. Maternal COVID-19 can also polarize fetal immunity, which may have long-term effects on neurodevelopment. Although the COVID-19 pandemic continues to evolve, the impact of emerging SARS-CoV-2 variants on placental and perinatal injury/mortality remains concerning for maternal and perinatal health. Here, we highlight the impact of COVID-19 on the placenta and fetus and remaining knowledge gaps.
摘要：
由于感染了严重急性呼吸道综合症冠状病毒2（SARS-CoV-2），孕妇及其胎儿很容易受到2019年冠状病毒疾病（COVID-19）的不利健康后果。COVID-19与更高的孕产妇死亡率有关，早产,和死产。虽然SARS-CoV-2感染胎盘和垂直传播很少见，这可能是由于产妇感染与胎盘和新生儿检测之间的时间间隔通常较长.在SARS-CoV-2相关死胎伴大量绒毛周围纤维蛋白沉积的情况下，胎盘损伤很明显，慢性组织细胞夹带炎，滋养细胞坏死.母体COVID-19还可以使胎儿免疫极化，可能对神经发育有长期影响。尽管COVID-19大流行继续演变，新出现的SARS-CoV-2变种对胎盘和围产期损伤/死亡率的影响仍然关系到孕产妇和围产期健康。这里,我们强调了COVID-19对胎盘和胎儿的影响以及剩余的知识差距。
