Abstract：
Synthesizing uniform functional covalent organic framework (COF) microspheres is the prerequisite of applying COFs as novel stationary phases for liquid chromatography. However, the synthesis of functionalized COF microspheres is challenging due to the difficulty in maintaining microspheric morphology when conferring functions. Here, a facile and universal \"self-limited dynamic linker exchange\" strategy is developed to achieve surface functionalization of uniform COF microspheres. Six different types of COF microspheres are constructed, showing the universality and superiority of the strategy. The library of COF microspheres\' stationary phases can be further enriched on demand by varying different functional building blocks. The \"self-limited dynamic linker exchange\" is attributed to the result of a delicate balance of reaction thermodynamics and molecular diffusion energy barrier. As a demonstration, the chiral functional COF microspheres are used as stationary phases of chiral chromatography and realized effective enantioseparation.
摘要：
合成均匀的功能共价有机骨架（COFs）微球是将COFs用作液相色谱的新型固定相的前提。然而,由于在赋予功能时难以维持微球形态,因此官能化COFs微球的合成具有挑战性。这里,我们开发了一种简单而通用的“自限动态接头交换”策略，以实现均匀COFs微球的表面官能化。构造了六种不同类型的COFs微球，显示了该战略的普遍性和优越性。COF微球固定相库可以根据需要通过改变不同的功能构建块来进一步丰富。“自限动态接头交换”归因于反应热力学和分子扩散能垒的微妙平衡。作为一个示范,手性功能性COFs微球作为手性色谱的固定相，实现了有效的对映体分离。本文受版权保护。保留所有权利。
