Abstract：
OBJECTIVE: Is fertility affected in women with multiple sclerosis (MS), and what is their usage of assisted reproductive technology (ART)?
METHODS: Data regarding multiple sclerosis and ART usage among patients with multiple sclerosis were extracted from the Israeli health maintenance organization Clalit Health Service database. Data regarding the diagnosis and treatment of multiple sclerosis, cause of infertility and use of fertility treatments were collected for all female multiple sclerosis patients aged 18-45 years between 2005 and 2021. Each patient was matched by age in a 1:10 ratio with reference women from the general population. The prevalence of infertility was compared between the two groups. Univariate and multivariate statistical tests were used to analyse the association between multiple sclerosis and fertility treatments including IVF and ovarian stimulation.
RESULTS: During the study period, 1309 multiple sclerosis patients were compared with 13,090 controls from the general population matched for age. The mean age was 29 ± 7.8 years. The overall prevalence of infertility was 15.4% (202/1309) among the multiple sclerosis patients, similar to the general population (16.3%; 2129/13090) (P = 0.436). The prevalence of IVF and ovarian stimulation was similar among multiple sclerosis patients and matched controls from the general population (8.1% versus 7.2%, P = 0.240; 13.8% versus 14.3%; P = 0.624, respectively).
CONCLUSIONS: The results show similar rates of infertility and fertility treatments among multiple sclerosis patients and the general population. This provides reassurance that fertility among women with multiple sclerosis does not differ from that of women in the general population, and indicates there is no excessive usage of ART.
METHODS: Data regarding multiple sclerosis and ART usage among patients with multiple sclerosis were extracted from the Israeli health maintenance organization Clalit Health Service database. Data regarding the diagnosis and treatment of multiple sclerosis, cause of infertility and use of fertility treatments were collected for all female multiple sclerosis patients aged 18-45 years between 2005 and 2021. Each patient was matched by age in a 1:10 ratio with reference women from the general population. The prevalence of infertility was compared between the two groups. Univariate and multivariate statistical tests were used to analyse the association between multiple sclerosis and fertility treatments including IVF and ovarian stimulation.
RESULTS: During the study period, 1309 multiple sclerosis patients were compared with 13,090 controls from the general population matched for age. The mean age was 29 ± 7.8 years. The overall prevalence of infertility was 15.4% (202/1309) among the multiple sclerosis patients, similar to the general population (16.3%; 2129/13090) (P = 0.436). The prevalence of IVF and ovarian stimulation was similar among multiple sclerosis patients and matched controls from the general population (8.1% versus 7.2%, P = 0.240; 13.8% versus 14.3%; P = 0.624, respectively).
CONCLUSIONS: The results show similar rates of infertility and fertility treatments among multiple sclerosis patients and the general population. This provides reassurance that fertility among women with multiple sclerosis does not differ from that of women in the general population, and indicates there is no excessive usage of ART.
摘要：
目标：多发性硬化症（MS）女性的生育能力受到影响，
方法：从以色列健康维护组织ClalitHealthService数据库中提取了有关多发性硬化症和多发性硬化症患者ART使用情况的数据。关于多发性硬化症的诊断和治疗的数据，收集了2005年至2021年间所有年龄为18-45岁的女性多发性硬化症患者的不孕症原因和生育治疗的使用情况.每位患者的年龄以1:10的比例与普通人群中的参考女性相匹配。比较两组患者的不孕症患病率。使用单变量和多变量统计检验来分析多发性硬化症与包括IVF和卵巢刺激在内的生育治疗之间的关联。
结果：在研究期间，将1309例多发性硬化症患者与年龄匹配的普通人群中的13090例对照进行了比较。平均年龄29±7.8岁。在多发性硬化症患者中，不孕的总患病率为15.4%(202/1309)，与普通人群相似(16.3%;2129/13090)(P=0.436)。在多发性硬化症患者和普通人群中，IVF和卵巢刺激的患病率相似（8.1％对7.2％，P=0.240；分别为13.8%和14.3%；P=0.624）。
结论：结果显示，多发性硬化症患者和普通人群的不孕症和生育治疗发生率相似。这保证了多发性硬化症妇女的生育能力与普通人群中的妇女没有区别，并表明没有过度使用ART。
方法：从以色列健康维护组织ClalitHealthService数据库中提取了有关多发性硬化症和多发性硬化症患者ART使用情况的数据。关于多发性硬化症的诊断和治疗的数据，收集了2005年至2021年间所有年龄为18-45岁的女性多发性硬化症患者的不孕症原因和生育治疗的使用情况.每位患者的年龄以1:10的比例与普通人群中的参考女性相匹配。比较两组患者的不孕症患病率。使用单变量和多变量统计检验来分析多发性硬化症与包括IVF和卵巢刺激在内的生育治疗之间的关联。
结果：在研究期间，将1309例多发性硬化症患者与年龄匹配的普通人群中的13090例对照进行了比较。平均年龄29±7.8岁。在多发性硬化症患者中，不孕的总患病率为15.4%(202/1309)，与普通人群相似(16.3%;2129/13090)(P=0.436)。在多发性硬化症患者和普通人群中，IVF和卵巢刺激的患病率相似（8.1％对7.2％，P=0.240；分别为13.8%和14.3%；P=0.624）。
结论：结果显示，多发性硬化症患者和普通人群的不孕症和生育治疗发生率相似。这保证了多发性硬化症妇女的生育能力与普通人群中的妇女没有区别，并表明没有过度使用ART。
