Abstract：
UNASSIGNED: Vitamin D is involved in several processes related to the development of neuronal and non-neuronal cells. There is a possible link between maternal vitamin D status in pregnancy and delayed neurocognitive development in the offspring. The aim of the study was to explore the association of maternal and cord blood vitamin D levels with infants\' neurodevelopment at 6 and 9 months of age.
UNASSIGNED: A cohort study was conducted in western Rajasthan, India. Maternal and cord blood samples were collected at the time of delivery. Serum 25(OH)-vitamin D levels were measured in both. Infant neurodevelopment was assessed at 6 and 9 months of age in six domains namely cognitive, receptive language, expressive language, fine motor, gross motor and social-emotional using the Bayley Scale of Infant Development- III (BSID-III).
UNASSIGNED: A total of 175 mother-child pairs were enrolled. Among the mothers taking part in this study, 7.3% had deficient and 59.09% had insufficient levels of serum 25(OH) vitamin D during the third trimester of their pregnancy. Maternal and cord blood serum 25-OH vitamin D levels were 18.86 ± 8.53 ng/mL and 17.39 ± 8.87 ng/mL, respectively, and there was a significant correlation (r = 0.9778, p = 0.000) between levels of vitamin D. Based on the repeated measures ANOVA, post hoc Tukey\'s HSD test, maternal vitamin D levels had a significant relationship (p = 0.047) to the cognitive development of infants at 6 months of age. Furthermore, cord serum vitamin D levels showed a significant association (p = 0.023 and p = 0.010) with the social-emotional development of the infant at the age of 6 and 9 months.
UNASSIGNED: Maternal and cord serum 25-OH vitamin D deficiency was significantly associated with the cognitive and social-emotional development of infants.
UNASSIGNED: A cohort study was conducted in western Rajasthan, India. Maternal and cord blood samples were collected at the time of delivery. Serum 25(OH)-vitamin D levels were measured in both. Infant neurodevelopment was assessed at 6 and 9 months of age in six domains namely cognitive, receptive language, expressive language, fine motor, gross motor and social-emotional using the Bayley Scale of Infant Development- III (BSID-III).
UNASSIGNED: A total of 175 mother-child pairs were enrolled. Among the mothers taking part in this study, 7.3% had deficient and 59.09% had insufficient levels of serum 25(OH) vitamin D during the third trimester of their pregnancy. Maternal and cord blood serum 25-OH vitamin D levels were 18.86 ± 8.53 ng/mL and 17.39 ± 8.87 ng/mL, respectively, and there was a significant correlation (r = 0.9778, p = 0.000) between levels of vitamin D. Based on the repeated measures ANOVA, post hoc Tukey\'s HSD test, maternal vitamin D levels had a significant relationship (p = 0.047) to the cognitive development of infants at 6 months of age. Furthermore, cord serum vitamin D levels showed a significant association (p = 0.023 and p = 0.010) with the social-emotional development of the infant at the age of 6 and 9 months.
UNASSIGNED: Maternal and cord serum 25-OH vitamin D deficiency was significantly associated with the cognitive and social-emotional development of infants.
摘要：
■维生素D参与与神经元和非神经元细胞发育有关的几个过程。孕妇在怀孕期间的维生素D状态与后代的神经认知发育延迟之间可能存在联系。该研究的目的是探讨母亲和脐带血维生素D水平与6个月和9个月婴儿神经发育的关系。
■在拉贾斯坦邦西部进行了一项队列研究，印度。在分娩时收集产妇和脐带血样品。同时测定血清25(OH)-维生素D水平。婴儿神经发育在6个月和9个月大的六个领域进行评估，即认知，接受语言,富有表现力的语言,精细电机，使用贝利婴儿发育量表-III(BSID-III)的粗大运动和社交情绪。
■总共登记了175对母子。在参与这项研究的母亲中，7.3%的人在妊娠晚期血清25(OH)维生素D缺乏，59.09%的人血清25(OH)维生素D水平不足。母亲和脐带血血清25-OH维生素D水平分别为18.86±8.53ng/mL和17.39±8.87ng/mL，分别,维生素D水平之间存在显着相关性（r=0.9778，p=0.000）。基于重复测量方差分析，事后Tukey的HSD测试，母体维生素D水平与6月龄婴儿的认知发育有显著关系(p=0.047).此外，脐带血维生素D水平与6个月和9个月大的婴儿的社会情绪发展显着相关（p=0.023和p=0.010）。
■母亲和脐血25-OH维生素D缺乏与婴儿的认知和社会情绪发展显著相关。
■在拉贾斯坦邦西部进行了一项队列研究，印度。在分娩时收集产妇和脐带血样品。同时测定血清25(OH)-维生素D水平。婴儿神经发育在6个月和9个月大的六个领域进行评估，即认知，接受语言,富有表现力的语言,精细电机，使用贝利婴儿发育量表-III(BSID-III)的粗大运动和社交情绪。
■总共登记了175对母子。在参与这项研究的母亲中，7.3%的人在妊娠晚期血清25(OH)维生素D缺乏，59.09%的人血清25(OH)维生素D水平不足。母亲和脐带血血清25-OH维生素D水平分别为18.86±8.53ng/mL和17.39±8.87ng/mL，分别,维生素D水平之间存在显着相关性（r=0.9778，p=0.000）。基于重复测量方差分析，事后Tukey的HSD测试，母体维生素D水平与6月龄婴儿的认知发育有显著关系(p=0.047).此外，脐带血维生素D水平与6个月和9个月大的婴儿的社会情绪发展显着相关（p=0.023和p=0.010）。
■母亲和脐血25-OH维生素D缺乏与婴儿的认知和社会情绪发展显著相关。
