Abstract：
OBJECTIVE: To evaluate the severity and prevalence of headache and facial pain/pressurere in the chronic rhinosinusitis (CRS) population.
METHODS: CINAHL, PubMed, Scopus.
METHODS: The literature was searched from inception through June 2023 for English language articles documenting \"headache\" or \"facial pain/pressure\" and \"chronic rhinosinusitis.\" Data collected included Lund-MacKay computed tomography score, Lund-Kennedy endoscopy score, sinonasal outcome test, and visual analog scale. Meta-analyses were performed on continuous measures (mean), proportions (%), and regression.
RESULTS: A total of 69 studies were included with 8643 CRS patients and 703 control patients. The CRS group had a mean age of 44.1 (range: 16-82; 95% confidence interval [CI]: 40.3-48) and 86.1% [95% CI: 76.4-93.5] with nasal polyposis. The control group had a mean age of 39.2 (range: 17-88; 95% CI: 28.7-49.8). All CRS subgroups had significantly more severe headache and facial pain/pressure when compared to the control (P < .0001). Patients without polyps had significantly more severe facial pain/pressure and headache when compared to patients with polyps (P < .0001). Facial pain/pressure is a moderate problem or worse in 29.8% of polypoid patients versus 56.4% of nonpolypoid patients; Δ26.6% [95% CI: 0.7-50; P = .045].
CONCLUSIONS: Across all outcome metrics, CRS patients experience significantly more severe headache and facial pain/pressure when compared to a control population. Nonpolypoid patients experience significantly more severe facial pain/pressure and headache when compared to polypoid patients. The majority of nonpolypoid patients experience facial pain/pressure that is moderate in severity or worse.
METHODS: CINAHL, PubMed, Scopus.
METHODS: The literature was searched from inception through June 2023 for English language articles documenting \"headache\" or \"facial pain/pressure\" and \"chronic rhinosinusitis.\" Data collected included Lund-MacKay computed tomography score, Lund-Kennedy endoscopy score, sinonasal outcome test, and visual analog scale. Meta-analyses were performed on continuous measures (mean), proportions (%), and regression.
RESULTS: A total of 69 studies were included with 8643 CRS patients and 703 control patients. The CRS group had a mean age of 44.1 (range: 16-82; 95% confidence interval [CI]: 40.3-48) and 86.1% [95% CI: 76.4-93.5] with nasal polyposis. The control group had a mean age of 39.2 (range: 17-88; 95% CI: 28.7-49.8). All CRS subgroups had significantly more severe headache and facial pain/pressure when compared to the control (P < .0001). Patients without polyps had significantly more severe facial pain/pressure and headache when compared to patients with polyps (P < .0001). Facial pain/pressure is a moderate problem or worse in 29.8% of polypoid patients versus 56.4% of nonpolypoid patients; Δ26.6% [95% CI: 0.7-50; P = .045].
CONCLUSIONS: Across all outcome metrics, CRS patients experience significantly more severe headache and facial pain/pressure when compared to a control population. Nonpolypoid patients experience significantly more severe facial pain/pressure and headache when compared to polypoid patients. The majority of nonpolypoid patients experience facial pain/pressure that is moderate in severity or worse.
摘要：
目的：评估慢性鼻窦炎（CRS）人群中头痛和面部疼痛/压力的严重程度和患病率。
方法：CINAHL，PubMed,Scopus.
方法：从研究开始到2023年6月，在文献中搜索“头痛”或“面部疼痛/压力”和“慢性鼻窦炎”的英文文章。“收集的数据包括Lund-MacKay计算机断层扫描评分，Lund-Kennedy内窥镜评分,鼻窦结局试验,和视觉模拟量表。对连续测量(平均值)、比例（%），和回归。
结果：共有69项研究纳入了8643例CRS患者和703例对照患者。CRS组的平均年龄为44.1岁（范围：16-82；95％置信区间[CI]：40.3-48）和86.1％[95％CI：76.4-93.5]。对照组的平均年龄为39.2岁（范围：17-88；95％CI：28.7-49.8）。与对照组相比，所有CRS亚组的头痛和面部疼痛/压力明显更严重（P<0.0001）。与息肉患者相比，无息肉患者的面部疼痛/压力和头痛明显更为严重（P<0.0001）。面部疼痛/压力在29.8％的息肉样患者中是中度问题或更严重，在非息肉样患者中为56.4％；Δ26.6％[95％CI：0.7-50；P=.045]。
结论：在所有结果指标中，当与对照人群相比时,CRS患者经历显著更严重的头痛和面部疼痛/压力。与息肉患者相比，非息肉患者的面部疼痛/压力和头痛明显更为严重。大多数非息肉样患者会出现严重程度中等或更严重的面部疼痛/压力。
方法：CINAHL，PubMed,Scopus.
方法：从研究开始到2023年6月，在文献中搜索“头痛”或“面部疼痛/压力”和“慢性鼻窦炎”的英文文章。“收集的数据包括Lund-MacKay计算机断层扫描评分，Lund-Kennedy内窥镜评分,鼻窦结局试验,和视觉模拟量表。对连续测量(平均值)、比例（%），和回归。
结果：共有69项研究纳入了8643例CRS患者和703例对照患者。CRS组的平均年龄为44.1岁（范围：16-82；95％置信区间[CI]：40.3-48）和86.1％[95％CI：76.4-93.5]。对照组的平均年龄为39.2岁（范围：17-88；95％CI：28.7-49.8）。与对照组相比，所有CRS亚组的头痛和面部疼痛/压力明显更严重（P<0.0001）。与息肉患者相比，无息肉患者的面部疼痛/压力和头痛明显更为严重（P<0.0001）。面部疼痛/压力在29.8％的息肉样患者中是中度问题或更严重，在非息肉样患者中为56.4％；Δ26.6％[95％CI：0.7-50；P=.045]。
结论：在所有结果指标中，当与对照人群相比时,CRS患者经历显著更严重的头痛和面部疼痛/压力。与息肉患者相比，非息肉患者的面部疼痛/压力和头痛明显更为严重。大多数非息肉样患者会出现严重程度中等或更严重的面部疼痛/压力。
