PDF(Pubmed)
Abstract：
UNASSIGNED: Diabetic foot ulcers are a severe complication in diabetic patients, significantly impact healthcare systems and patient quality of life, often leading to hospitalization and amputation. Traditional Standard of Care (SOC) treatments are inadequate for many patients, necessitating advanced wound care products (AWCPs) like human placental membranes. This study conducts a retrospective analysis to compare the effectiveness of two human placental membrane products, retention-processed amnion chorion (RE-AC) and lamination-processed amnion chorion (L-AC) in managing chronic diabetic foot ulcers (DFUs).
UNASSIGNED: The study collected retrospective observational data from electronic health records (EHRs) of patients treated for DFU at three outpatient wound care centers. Patients were categorized into two cohorts based on the treatment received. Key metrics included wound size progression and the number of product applications. The analysis employed Bayesian estimation, utilizing an analysis of covariance model with a Hurdle Gamma likelihood.
UNASSIGNED: We found that RE-AC achieved a marginally higher expected Percent Area Reduction (xPAR) in DFUs compared to L-AC at 12 weeks (67.3% vs. 52.6%). RE-AC also required fewer applications, suggesting greater efficiency in general wound closure. Probability of full wound closure was similar in both groups (0.738 vs 0.740 in RE-AC and L-AC, respectively).
UNASSIGNED: The findings suggest that while L-AC might be slightly more effective in complete ulcer healing, RE-AC offers overall better treatment efficiency, especially in reducing the frequency of applications. This efficiency can lead to improved patient comfort, reduced treatment costs, and optimized resource utilization in healthcare settings.
UNASSIGNED: The study collected retrospective observational data from electronic health records (EHRs) of patients treated for DFU at three outpatient wound care centers. Patients were categorized into two cohorts based on the treatment received. Key metrics included wound size progression and the number of product applications. The analysis employed Bayesian estimation, utilizing an analysis of covariance model with a Hurdle Gamma likelihood.
UNASSIGNED: We found that RE-AC achieved a marginally higher expected Percent Area Reduction (xPAR) in DFUs compared to L-AC at 12 weeks (67.3% vs. 52.6%). RE-AC also required fewer applications, suggesting greater efficiency in general wound closure. Probability of full wound closure was similar in both groups (0.738 vs 0.740 in RE-AC and L-AC, respectively).
UNASSIGNED: The findings suggest that while L-AC might be slightly more effective in complete ulcer healing, RE-AC offers overall better treatment efficiency, especially in reducing the frequency of applications. This efficiency can lead to improved patient comfort, reduced treatment costs, and optimized resource utilization in healthcare settings.
摘要：
■糖尿病足溃疡是糖尿病患者的严重并发症，显着影响医疗保健系统和患者生活质量，常导致住院和截肢。传统的护理标准（SOC）治疗对许多患者来说是不够的，需要先进的伤口护理产品（AWCP），如人胎盘膜。这项研究进行了回顾性分析，以比较两种人胎盘膜产品的有效性，保留处理的羊膜绒毛膜（RE-AC）和层压处理的羊膜绒毛膜（L-AC）治疗慢性糖尿病足溃疡（DFU）。
■该研究从三个门诊伤口护理中心接受DFU治疗的患者的电子健康记录（EHR）中收集了回顾性观察数据。根据接受的治疗将患者分为两组。关键指标包括伤口大小的进展和产品应用的数量。分析采用贝叶斯估计，利用带跨栏伽马似然的协方差模型分析。
■我们发现，与12周时的L-AC相比，RE-AC在DFU中的预期面积减少百分比（xPAR）略高（67.3％vs.52.6%）。RE-AC还需要更少的应用程序，表明一般伤口闭合效率更高。两组完全伤口闭合的概率相似(RE-AC和L-AC为0.738vs0.740,分别)。
■研究结果表明，虽然L-AC在溃疡完全愈合方面可能更有效，RE-AC提供整体更好的治疗效率，尤其是在降低应用频率方面。这种效率可以提高患者的舒适度，降低治疗成本，和优化医疗保健环境中的资源利用。
■该研究从三个门诊伤口护理中心接受DFU治疗的患者的电子健康记录（EHR）中收集了回顾性观察数据。根据接受的治疗将患者分为两组。关键指标包括伤口大小的进展和产品应用的数量。分析采用贝叶斯估计，利用带跨栏伽马似然的协方差模型分析。
■我们发现，与12周时的L-AC相比，RE-AC在DFU中的预期面积减少百分比（xPAR）略高（67.3％vs.52.6%）。RE-AC还需要更少的应用程序，表明一般伤口闭合效率更高。两组完全伤口闭合的概率相似(RE-AC和L-AC为0.738vs0.740,分别)。
■研究结果表明，虽然L-AC在溃疡完全愈合方面可能更有效，RE-AC提供整体更好的治疗效率，尤其是在降低应用频率方面。这种效率可以提高患者的舒适度，降低治疗成本，和优化医疗保健环境中的资源利用。
