PDF(Pubmed)
Abstract：
UNASSIGNED: To introduce MexOMICS, a Mexican Consortium focused on establishing electronic databases to collect, cross-reference, and share health-related and omics data on the Mexican population.
UNASSIGNED: Since 2019, the MexOMICS Consortium has established three electronic-based registries: the Mexican Twin Registry (TwinsMX), Mexican Lupus Registry (LupusRGMX), and the Mexican Parkinson\'s Research Network (MEX-PD), designed and implemented using the Research Electronic Data Capture web-based application. Participants were enrolled through voluntary participation and on-site engagement with medical specialists. We also acquired DNA samples and Magnetic Resonance Imaging scans in subsets of participants.
UNASSIGNED: The registries have successfully enrolled a large number of participants from a variety of regions within Mexico: TwinsMX (n = 2,915), LupusRGMX (n = 1,761) and MEX-PD (n = 750). In addition to sociodemographic, psychosocial, and clinical data, MexOMICS has collected DNA samples to study the genetic biomarkers across the three registries. Cognitive function has been assessed with the Montreal Cognitive Assessment in a subset of 376 MEX-PD participants. Furthermore, a subset of 267 twins have participated in cognitive evaluations with the Creyos platform and in MRI sessions acquiring structural, functional, and spectroscopy brain imaging; comparable evaluations are planned for LupusRGMX and MEX-PD.
UNASSIGNED: The MexOMICS registries offer a valuable repository of information concerning the potential interplay of genetic and environmental factors in health conditions among the Mexican population.
UNASSIGNED: Since 2019, the MexOMICS Consortium has established three electronic-based registries: the Mexican Twin Registry (TwinsMX), Mexican Lupus Registry (LupusRGMX), and the Mexican Parkinson\'s Research Network (MEX-PD), designed and implemented using the Research Electronic Data Capture web-based application. Participants were enrolled through voluntary participation and on-site engagement with medical specialists. We also acquired DNA samples and Magnetic Resonance Imaging scans in subsets of participants.
UNASSIGNED: The registries have successfully enrolled a large number of participants from a variety of regions within Mexico: TwinsMX (n = 2,915), LupusRGMX (n = 1,761) and MEX-PD (n = 750). In addition to sociodemographic, psychosocial, and clinical data, MexOMICS has collected DNA samples to study the genetic biomarkers across the three registries. Cognitive function has been assessed with the Montreal Cognitive Assessment in a subset of 376 MEX-PD participants. Furthermore, a subset of 267 twins have participated in cognitive evaluations with the Creyos platform and in MRI sessions acquiring structural, functional, and spectroscopy brain imaging; comparable evaluations are planned for LupusRGMX and MEX-PD.
UNASSIGNED: The MexOMICS registries offer a valuable repository of information concerning the potential interplay of genetic and environmental factors in health conditions among the Mexican population.
摘要：
■要介绍MexOMICS，墨西哥财团专注于建立电子数据库来收集，交叉引用，并分享墨西哥人口的健康相关数据和组学数据。
■自2019年以来，MexOMICS联盟建立了三个基于电子的注册管理机构：墨西哥孪生注册管理机构（TwinsMX），墨西哥狼疮登记处（LupusRGMX），和墨西哥帕金森研究网络(MEX-PD)，使用基于Web的研究电子数据捕获应用程序进行设计和实现。参与者通过自愿参与和与医学专家的现场接触进行注册。我们还获得了参与者子集的DNA样本和磁共振成像扫描。
■注册管理机构已成功注册了来自墨西哥各个地区的大量参与者：TwinsMX（n=2,915），LupusRGMX（n=1,761）和MEX-PD（n=750）。除了社会人口统计学，社会心理,和临床数据，MexOMICS收集了DNA样本，以研究三个注册表中的遗传生物标志物。已通过蒙特利尔认知评估对376名MEX-PD参与者的子集进行了认知功能评估。此外，267对双胞胎的一个子集参与了Creyos平台的认知评估，并参与了MRI课程，功能，和光谱学脑成像；计划对LupusRGMX和MEX-PD进行可比评估。
■MexOMICS注册中心提供了有关墨西哥人口中遗传和环境因素在健康状况中潜在相互作用的有价值的信息库。
■自2019年以来，MexOMICS联盟建立了三个基于电子的注册管理机构：墨西哥孪生注册管理机构（TwinsMX），墨西哥狼疮登记处（LupusRGMX），和墨西哥帕金森研究网络(MEX-PD)，使用基于Web的研究电子数据捕获应用程序进行设计和实现。参与者通过自愿参与和与医学专家的现场接触进行注册。我们还获得了参与者子集的DNA样本和磁共振成像扫描。
■注册管理机构已成功注册了来自墨西哥各个地区的大量参与者：TwinsMX（n=2,915），LupusRGMX（n=1,761）和MEX-PD（n=750）。除了社会人口统计学，社会心理,和临床数据，MexOMICS收集了DNA样本，以研究三个注册表中的遗传生物标志物。已通过蒙特利尔认知评估对376名MEX-PD参与者的子集进行了认知功能评估。此外，267对双胞胎的一个子集参与了Creyos平台的认知评估，并参与了MRI课程，功能，和光谱学脑成像；计划对LupusRGMX和MEX-PD进行可比评估。
■MexOMICS注册中心提供了有关墨西哥人口中遗传和环境因素在健康状况中潜在相互作用的有价值的信息库。
