PDF(Pubmed)
Abstract：
UNASSIGNED: Electrolyte disorder (ED) is frequently encountered critically ill patients during admission or admission to the intensive care unit (ICU). This study aimed to determine the frequency of ED encountered in ICU patients to evaluate the relationship of ED with drugs.
UNASSIGNED: This prospective, multicenter study was conducted in the medical and anesthesiology ICUs of two training and research hospitals and included patients with at least one ED during admission or hospitalization in the ICUs. The relationship between ED and the drug was evaluated by calculating the logistic probabilistic method scale (LPMS) and the expert panel\'s evaluation. The correlation between EDs and LPMS was determined using Kendal tau. A binary logistic regression model was preferred in the analysis of factors related to ED. Statistical significance was set as p < 0.05.
UNASSIGNED: A total of 117 patients were included in the study. A total of 165 EDs were detected, including at least one in 88 (75.2%) patients. According to the expert panel, 61 (21.7%) of EDs were drug-related, whereas according to the LPMS, 111 (39.6%) (p < 0.001). Mortality (50% vs. 13.7%) and mechanical ventilation rates (52.2% vs. 17.2%) were significantly higher in patients with ED (p < 0.001). Patients with ED had 8.352 times higher odds of exhibiting mortality (OR: 8.352, %95 CI: 1.598-43.648, p: 0.012) and need mechanical ventilation with higher odds of 3.229 (OR: 3.229 95% CI: 0.815-12.787 p: 0.045). Patient who required enteral or parenteral feeding were associated with an increased likelihood of exhibiting ED (respectively OR: 30.057, %95 CI: 2.265-398.892, p: 0.01, OR: 5.537, %95 CI: 1.406-21.800, p: 0.014).
UNASSIGNED: EDs are very common in the ICU. Dysnatremia was detected more commonly in other EDs. It has also been found that patients with ED are more often under mechanical ventilation, have more prolonged hospitalizations, and have higher mortality rates than patients without ED. The suitability of LPMS for assessing ED-drug relationships in the ICU context is questioned.
UNASSIGNED: This prospective, multicenter study was conducted in the medical and anesthesiology ICUs of two training and research hospitals and included patients with at least one ED during admission or hospitalization in the ICUs. The relationship between ED and the drug was evaluated by calculating the logistic probabilistic method scale (LPMS) and the expert panel\'s evaluation. The correlation between EDs and LPMS was determined using Kendal tau. A binary logistic regression model was preferred in the analysis of factors related to ED. Statistical significance was set as p < 0.05.
UNASSIGNED: A total of 117 patients were included in the study. A total of 165 EDs were detected, including at least one in 88 (75.2%) patients. According to the expert panel, 61 (21.7%) of EDs were drug-related, whereas according to the LPMS, 111 (39.6%) (p < 0.001). Mortality (50% vs. 13.7%) and mechanical ventilation rates (52.2% vs. 17.2%) were significantly higher in patients with ED (p < 0.001). Patients with ED had 8.352 times higher odds of exhibiting mortality (OR: 8.352, %95 CI: 1.598-43.648, p: 0.012) and need mechanical ventilation with higher odds of 3.229 (OR: 3.229 95% CI: 0.815-12.787 p: 0.045). Patient who required enteral or parenteral feeding were associated with an increased likelihood of exhibiting ED (respectively OR: 30.057, %95 CI: 2.265-398.892, p: 0.01, OR: 5.537, %95 CI: 1.406-21.800, p: 0.014).
UNASSIGNED: EDs are very common in the ICU. Dysnatremia was detected more commonly in other EDs. It has also been found that patients with ED are more often under mechanical ventilation, have more prolonged hospitalizations, and have higher mortality rates than patients without ED. The suitability of LPMS for assessing ED-drug relationships in the ICU context is questioned.
摘要：
■电解质紊乱（ED）是在入院或入住重症监护病房（ICU）期间经常遇到的危重病人。本研究旨在确定ICU患者遇到ED的频率，以评估ED与药物的关系。
■这个前景，多中心研究是在两家培训和研究医院的医疗和麻醉科ICU中进行的,纳入了ICU入院或住院期间至少有1例ED的患者.通过计算逻辑概率法量表(LPMS)和专家小组评价评价ED与药物的关系。使用Kendaltau确定ED和LPMS之间的相关性。在分析与ED相关的因素时，首选二元逻辑回归模型。统计学显著性设定为p<0.05。
■总共117名患者被纳入研究。共检测到165个ED，88例患者中至少有1例（75.2%）。根据专家小组的说法，61(21.7%)的ED与药物有关，而根据LPMS，111（39.6%）（p<0.001）。死亡率（50%vs.13.7%）和机械通气率（52.2%vs.17.2％）显着高于ED患者（p<0.001）。ED患者的死亡率高8.352倍（OR：8.352，％95CI：1.598-43.648，p：0.012），需要机械通气的几率更高，为3.229（OR：3.22995％CI：0.815-12.787p：0.045）。需要肠内或肠胃外喂养的患者出现ED的可能性增加(分别为OR:30.057,%95CI:2.265-398.892,p:0.01,OR:5.537,%95CI:1.406-21.800,p:0.014)。
■ED在ICU中非常常见。在其他ED中更常见的是失语症。还发现，ED患者更经常接受机械通气，住院时间更长，且死亡率高于无ED患者。LPMS用于评估ICU环境中ED-药物关系的适用性受到质疑。
■这个前景，多中心研究是在两家培训和研究医院的医疗和麻醉科ICU中进行的,纳入了ICU入院或住院期间至少有1例ED的患者.通过计算逻辑概率法量表(LPMS)和专家小组评价评价ED与药物的关系。使用Kendaltau确定ED和LPMS之间的相关性。在分析与ED相关的因素时，首选二元逻辑回归模型。统计学显著性设定为p<0.05。
■总共117名患者被纳入研究。共检测到165个ED，88例患者中至少有1例（75.2%）。根据专家小组的说法，61(21.7%)的ED与药物有关，而根据LPMS，111（39.6%）（p<0.001）。死亡率（50%vs.13.7%）和机械通气率（52.2%vs.17.2％）显着高于ED患者（p<0.001）。ED患者的死亡率高8.352倍（OR：8.352，％95CI：1.598-43.648，p：0.012），需要机械通气的几率更高，为3.229（OR：3.22995％CI：0.815-12.787p：0.045）。需要肠内或肠胃外喂养的患者出现ED的可能性增加(分别为OR:30.057,%95CI:2.265-398.892,p:0.01,OR:5.537,%95CI:1.406-21.800,p:0.014)。
■ED在ICU中非常常见。在其他ED中更常见的是失语症。还发现，ED患者更经常接受机械通气，住院时间更长，且死亡率高于无ED患者。LPMS用于评估ICU环境中ED-药物关系的适用性受到质疑。
