PDF(Pubmed)
Abstract：
Malacoplakia is a rare chronic granulomatous disease that mostly affects the gastrointestinal tract and urinary tract of immunocompromised patients; malacoplakia rarely effects the female reproductive tract. Here, we report a 56-year-old patient who underwent thymectomy for thymoma and myasthenia gravis prior to developing cervical and vaginal malacoplakia. The patient presented with recurrent vaginal bleeding. We discovered that there were alterations in the cervical cauliflower pattern during colposcopy, which is suggestive of cervical cancer. Pathological examination of the lesion tissue showed that a large number of macrophages aggregated, and M-G bodies with concentric circles and refractive properties were observed between cells. Immunostaining for CD68 and CD163 was positive, and special staining for D-PAS and PAS was positive. The discovery of Escherichia coli in bacterial culture can aid in the diagnosis of malacoplakia. Following surgery, we performed vaginal lavage with antibiotics in addition to resection of local cervical and vaginal lesions. This study provides a fresh perspective on the management of genital malacoplakia.
摘要：
软化斑是一种罕见的慢性肉芽肿性疾病，主要影响免疫功能低下患者的胃肠道和泌尿道；软化斑很少影响女性生殖道。这里,我们报道了1例56岁的患者,在发生宫颈和阴道软斑之前,接受了胸腺瘤和重症肌无力的胸腺切除术.患者出现复发性阴道出血。我们发现阴道镜检查时宫颈花椰菜模式有改变，这暗示了宫颈癌.病变组织病理检查显示大量巨噬细胞聚集,在细胞之间观察到具有同心圆和屈光特性的M-G体。CD68和CD163的免疫染色为阳性，D-PAS和PAS特殊染色阳性。在细菌培养中发现大肠杆菌有助于诊断软骨病。手术后,除了切除局部宫颈和阴道病变外，我们还进行了抗生素阴道灌洗。本研究为生殖器软斑的治疗提供了新的视角。
