PDF(Pubmed)
Abstract：
UNASSIGNED: Transcranial focused ultrasound (TFUS) is an emerging neuromodulation tool for temporarily altering brain activity and probing network functioning. The effects of TFUS on the default mode network (DMN) are unknown.
UNASSIGNED: The study examined the effects of transcranial focused ultrasound (TFUS) on the functional connectivity of the default mode network (DMN), specifically by targeting the posterior cingulate cortex (PCC). Additionally, we investigated the subjective effects of TFUS on mood, mindfulness, and self-related processing.
UNASSIGNED: The study employed a randomized, single-blind design involving 30 healthy subjects. Participants were randomly assigned to either the active TFUS group or the sham TFUS group. Resting-state functional magnetic resonance imaging (rs-fMRI) scans were conducted before and after the TFUS application. To measure subjective effects, the Toronto Mindfulness Scale, the Visual Analog Mood Scale, and the Amsterdam Resting State Questionnaire were administered at baseline and 30 min after sonication. The Self Scale and an unstructured interview were also administered 30 min after sonication.
UNASSIGNED: The active TFUS group exhibited significant reductions in functional connectivity along the midline of the DMN, while the sham TFUS group showed no changes. The active TFUS group demonstrated increased state mindfulness, reduced Global Vigor, and temporary alterations in the sense of ego, sense of time, and recollection of memories. The sham TFUS group showed an increase in state mindfulness, too, with no other subjective effects.
UNASSIGNED: TFUS targeted at the PCC can alter DMN connectivity and cause changes in subjective experience. These findings support the potential of TFUS to serve both as a research tool and as a potential therapeutic intervention.
UNASSIGNED: The study examined the effects of transcranial focused ultrasound (TFUS) on the functional connectivity of the default mode network (DMN), specifically by targeting the posterior cingulate cortex (PCC). Additionally, we investigated the subjective effects of TFUS on mood, mindfulness, and self-related processing.
UNASSIGNED: The study employed a randomized, single-blind design involving 30 healthy subjects. Participants were randomly assigned to either the active TFUS group or the sham TFUS group. Resting-state functional magnetic resonance imaging (rs-fMRI) scans were conducted before and after the TFUS application. To measure subjective effects, the Toronto Mindfulness Scale, the Visual Analog Mood Scale, and the Amsterdam Resting State Questionnaire were administered at baseline and 30 min after sonication. The Self Scale and an unstructured interview were also administered 30 min after sonication.
UNASSIGNED: The active TFUS group exhibited significant reductions in functional connectivity along the midline of the DMN, while the sham TFUS group showed no changes. The active TFUS group demonstrated increased state mindfulness, reduced Global Vigor, and temporary alterations in the sense of ego, sense of time, and recollection of memories. The sham TFUS group showed an increase in state mindfulness, too, with no other subjective effects.
UNASSIGNED: TFUS targeted at the PCC can alter DMN connectivity and cause changes in subjective experience. These findings support the potential of TFUS to serve both as a research tool and as a potential therapeutic intervention.
摘要：
■经颅聚焦超声（TFUS）是一种新兴的神经调节工具，用于暂时改变大脑活动和探测网络功能。TFUS对默认模式网络(DMN)的影响是未知的。
■研究检查了经颅聚焦超声（TFUS）对默认模式网络（DMN）的功能连通性的影响，特别是针对后扣带皮质（PCC）。此外,我们调查了TFUS对情绪的主观影响，正念,和自我相关的处理。
■这项研究采用了随机，涉及30名健康受试者的单盲设计。参与者被随机分配到活性TFUS组或假TFUS组。在TFUS应用前后进行静息状态功能磁共振成像（rs-fMRI）扫描。为了衡量主观效果，多伦多正念量表，视觉模拟情绪量表，在基线和超声处理后30分钟进行阿姆斯特丹静息状态问卷。超声处理后30分钟，还进行了自我量表和非结构化访谈。
■活动的TFUS组沿DMN中线的功能连通性显着降低，而假TFUS组无变化。活跃的TFUS组表现出增加的状态正念，降低全球活力，和自我意义上的暂时改变，时间感,和回忆的回忆。假TFUS组显示状态正念增加，也是,没有其他主观影响。
■针对PCC的TFUS可以改变DMN连接并导致主观体验的变化。这些发现支持TFUS作为研究工具和潜在治疗干预的潜力。
■研究检查了经颅聚焦超声（TFUS）对默认模式网络（DMN）的功能连通性的影响，特别是针对后扣带皮质（PCC）。此外,我们调查了TFUS对情绪的主观影响，正念,和自我相关的处理。
■这项研究采用了随机，涉及30名健康受试者的单盲设计。参与者被随机分配到活性TFUS组或假TFUS组。在TFUS应用前后进行静息状态功能磁共振成像（rs-fMRI）扫描。为了衡量主观效果，多伦多正念量表，视觉模拟情绪量表，在基线和超声处理后30分钟进行阿姆斯特丹静息状态问卷。超声处理后30分钟，还进行了自我量表和非结构化访谈。
■活动的TFUS组沿DMN中线的功能连通性显着降低，而假TFUS组无变化。活跃的TFUS组表现出增加的状态正念，降低全球活力，和自我意义上的暂时改变，时间感,和回忆的回忆。假TFUS组显示状态正念增加，也是,没有其他主观影响。
■针对PCC的TFUS可以改变DMN连接并导致主观体验的变化。这些发现支持TFUS作为研究工具和潜在治疗干预的潜力。
