PDF(Pubmed)
Abstract：
UNASSIGNED: The application of indices in the context of metabolic dysfunction-associated steatotic liver disease (MASLD) remains unexplored. We aimed to validate the ability of alanine aminotransferase (ALT), fatty liver index (FLI), and hepatic steatosis index (HSI) to identify MASLD during health checkups.
UNASSIGNED: We recruited 627 participants and utilized their health checkup data and ultrasound to assess the potential of using ALT, FLI, and HSI as indices for MASLD; this was indicated by the area under the curve (AUC) and restricted cubic spline (RCS) model. The optimal, rule-out (sensitivity ≥90%), and rule-in (specificity ≥90%) cutoff values of each index for identifying MASLD were reported.
UNASSIGNED: Among participants with a median age of 46 years, the prevalence of MASLD was 28% in total (38% in males and 18% in females). RCS models confirmed a linear association between indices and MASLD. ROC analyses indicated that the AUC of ALT in identifying MASLD was 0.79 for the total cohort, 0.81 for males, and 0.69 for females. The optimal, rule-out, and rule-in cutoff values for ALT were 21, 13, and 29, respectively. Similarly, the AUC of FLI/HSI in identifying MASLD was 0.90/0.88 for the total cohort, 0.86/0.85 for males, and 0.93/0.90 for females. Considering the reference cutoff values, distinct cutoff values were observed between the sexes for FLI, while HSI had similar cutoff values.
UNASSIGNED: This study demonstrated that ALT > 30 IU/L is a reasonable cutoff value to rule-in MASLD. ALT, FLI, and HSI are reliable indices for identifying MASLD during health checkups.
UNASSIGNED: We recruited 627 participants and utilized their health checkup data and ultrasound to assess the potential of using ALT, FLI, and HSI as indices for MASLD; this was indicated by the area under the curve (AUC) and restricted cubic spline (RCS) model. The optimal, rule-out (sensitivity ≥90%), and rule-in (specificity ≥90%) cutoff values of each index for identifying MASLD were reported.
UNASSIGNED: Among participants with a median age of 46 years, the prevalence of MASLD was 28% in total (38% in males and 18% in females). RCS models confirmed a linear association between indices and MASLD. ROC analyses indicated that the AUC of ALT in identifying MASLD was 0.79 for the total cohort, 0.81 for males, and 0.69 for females. The optimal, rule-out, and rule-in cutoff values for ALT were 21, 13, and 29, respectively. Similarly, the AUC of FLI/HSI in identifying MASLD was 0.90/0.88 for the total cohort, 0.86/0.85 for males, and 0.93/0.90 for females. Considering the reference cutoff values, distinct cutoff values were observed between the sexes for FLI, while HSI had similar cutoff values.
UNASSIGNED: This study demonstrated that ALT > 30 IU/L is a reasonable cutoff value to rule-in MASLD. ALT, FLI, and HSI are reliable indices for identifying MASLD during health checkups.
摘要：
■在代谢功能障碍相关的脂肪变性肝病（MASLD）的背景下，指标的应用仍未探索。我们旨在验证丙氨酸转氨酶（ALT）的能力，脂肪肝指数（FLI），和肝脂肪变性指数（HSI），以确定健康检查期间的MASLD。
■我们招募了627名参与者，并利用他们的健康检查数据和超声波来评估使用ALT的潜力。FLI,和HSI作为MASLD的指标；这通过曲线下面积（AUC）和受限三次样条（RCS）模型来表示。最优的,排除（灵敏度≥90%），并报告了用于识别MASLD的每个指标的规则(特异性≥90%)截断值.
■在平均年龄为46岁的参与者中，MASLD的总患病率为28%(男性为38%,女性为18%).RCS模型证实了指数与MASLD之间的线性关系。ROC分析表明，ALT在识别MASLD的AUC为0.79总队列，男性为0.81，女性为0.69。最优的,排除,ALT和规则截止值分别为21,13和29.同样，FLI/HSI在识别MASLD方面的AUC为总队列的0.90/0.88，男性为0.86/0.85，女性为0.93/0.90。考虑到参考截止值，在FLI的性别之间观察到不同的截止值，而恒生指数的临界值相似。
■这项研究表明，ALT>30IU/L是MASLD规则的合理截止值。ALT,FLI,和HSI是在健康检查期间识别MASLD的可靠指标。
■我们招募了627名参与者，并利用他们的健康检查数据和超声波来评估使用ALT的潜力。FLI,和HSI作为MASLD的指标；这通过曲线下面积（AUC）和受限三次样条（RCS）模型来表示。最优的,排除（灵敏度≥90%），并报告了用于识别MASLD的每个指标的规则(特异性≥90%)截断值.
■在平均年龄为46岁的参与者中，MASLD的总患病率为28%(男性为38%,女性为18%).RCS模型证实了指数与MASLD之间的线性关系。ROC分析表明，ALT在识别MASLD的AUC为0.79总队列，男性为0.81，女性为0.69。最优的,排除,ALT和规则截止值分别为21,13和29.同样，FLI/HSI在识别MASLD方面的AUC为总队列的0.90/0.88，男性为0.86/0.85，女性为0.93/0.90。考虑到参考截止值，在FLI的性别之间观察到不同的截止值，而恒生指数的临界值相似。
■这项研究表明，ALT>30IU/L是MASLD规则的合理截止值。ALT,FLI,和HSI是在健康检查期间识别MASLD的可靠指标。
