PDF(Pubmed)
Abstract：
UNASSIGNED: Various stemness markers (SOX2, OCT4, and NANOG) have been studied in odontogenic cysts and tumors. However, studies on SALL4 having similar properties of stemness has not been documented. Additionally, insight into fascin as a migratory molecule is less explored. In this study, the expression of SALL4 and fascin were evaluated in ameloblastoma, adenomatoid odontogenic tumor (AOT), odontogenic keratocyst (OKC), dentigerous cyst (DC), radicular cyst (RC), and calcifying odontogenic cyst (COC).
UNASSIGNED: Semi-quantitative analysis of fascin and SALL4 immuno-positive cells was done in a total of 40 cases of ameloblastoma (11 plexiform, 12 follicular, 12 unicystic, and 5 desmoplastic) variants, 6 cases of AOT, 15 each of OKC, DC, RC and 5 of COC. Chi-square test was applied to evaluate the association between SALL4 and fascin expression in odontogenic cysts and tumors.
UNASSIGNED: Fascin immunopositivity was observed in peripheral ameloblast-like cells, and weak or absent in stellate reticulum-like cells. A moderate to weak immune-reactivity to SALL4 was observed in the cytoplasm of ameloblastoma, epithelial cells of dentigerous and radicular cysts, having a marked inflammatory infiltrate, which is an interesting observation. COC and AOT had negative to weak expressions. No recurrence has been reported.
UNASSIGNED: Expression of fascin in ameloblastomas elucidate their role in motility and localized invasion. Its expression in less aggressive lesions like DC, COC, AOT will incite to explore the other functional properties of fascin. SALL4 expression in the cytoplasm of odontogenic cysts and tumors may represent inactive or mutant forms which requires further validation.
UNASSIGNED: Semi-quantitative analysis of fascin and SALL4 immuno-positive cells was done in a total of 40 cases of ameloblastoma (11 plexiform, 12 follicular, 12 unicystic, and 5 desmoplastic) variants, 6 cases of AOT, 15 each of OKC, DC, RC and 5 of COC. Chi-square test was applied to evaluate the association between SALL4 and fascin expression in odontogenic cysts and tumors.
UNASSIGNED: Fascin immunopositivity was observed in peripheral ameloblast-like cells, and weak or absent in stellate reticulum-like cells. A moderate to weak immune-reactivity to SALL4 was observed in the cytoplasm of ameloblastoma, epithelial cells of dentigerous and radicular cysts, having a marked inflammatory infiltrate, which is an interesting observation. COC and AOT had negative to weak expressions. No recurrence has been reported.
UNASSIGNED: Expression of fascin in ameloblastomas elucidate their role in motility and localized invasion. Its expression in less aggressive lesions like DC, COC, AOT will incite to explore the other functional properties of fascin. SALL4 expression in the cytoplasm of odontogenic cysts and tumors may represent inactive or mutant forms which requires further validation.
摘要：
■已经在牙源性囊肿和肿瘤中研究了各种干性标记（SOX2，OCT4和NANOG）。然而,关于SALL4具有类似干性特性的研究尚未记录。此外,对fascin作为一种迁移分子的洞察力研究较少。在这项研究中,SALL4和fascin在成釉细胞瘤中的表达，腺瘤样牙源性肿瘤（AOT），牙源性角化囊肿（OKC），牙质囊肿（DC），根性囊肿(RC),和牙源性钙化囊肿（COC）。
■在总共40例成釉细胞瘤中对fascin和SALL4免疫阳性细胞进行了半定量分析（11个丛状，12个卵泡，12个独木舟，和5个去可塑性）变体，6例AOT，OKC各15个，DC,RC和COC的5。卡方检验用于评估SALL4和fascin在牙源性囊肿和肿瘤中的表达之间的关联。
■在外周成釉细胞样细胞中观察到Fascin免疫阳性，星状网状细胞弱或无。在成釉细胞瘤的细胞质中观察到对SALL4的中度至弱免疫反应性，牙根囊肿上皮细胞，有明显的炎症浸润，这是一个有趣的观察。COC和AOT呈阴性至弱表达。没有复发的报道。
■成釉细胞瘤中fascin的表达阐明了其在运动和局部侵袭中的作用。它在侵袭性较小的病变如DC中表达，COC,AOT将激发探索fascin的其他功能特性。SALL4在牙源性囊肿和肿瘤的细胞质中的表达可能代表非活性或突变形式，需要进一步验证。
■在总共40例成釉细胞瘤中对fascin和SALL4免疫阳性细胞进行了半定量分析（11个丛状，12个卵泡，12个独木舟，和5个去可塑性）变体，6例AOT，OKC各15个，DC,RC和COC的5。卡方检验用于评估SALL4和fascin在牙源性囊肿和肿瘤中的表达之间的关联。
■在外周成釉细胞样细胞中观察到Fascin免疫阳性，星状网状细胞弱或无。在成釉细胞瘤的细胞质中观察到对SALL4的中度至弱免疫反应性，牙根囊肿上皮细胞，有明显的炎症浸润，这是一个有趣的观察。COC和AOT呈阴性至弱表达。没有复发的报道。
■成釉细胞瘤中fascin的表达阐明了其在运动和局部侵袭中的作用。它在侵袭性较小的病变如DC中表达，COC,AOT将激发探索fascin的其他功能特性。SALL4在牙源性囊肿和肿瘤的细胞质中的表达可能代表非活性或突变形式，需要进一步验证。
