PDF(Pubmed)
Abstract：
Bioengineering and drug delivery technologies play an important role in bridging the gap between basic scientific discovery and clinical application of therapeutics. To identify the optimal treatment, the most critical stage is to diagnose the problem. Often these two may occur simultaneously or in parallel, but in this review, we focus on bottom-up approaches in understanding basic immunologic phenomena to develop targeted therapeutics. This can be observed in several fields; here, we will focus on one of the original immunotherapy targets-cancer-and one of the more recent targets-regenerative medicine. By understanding how our immune system responds in processes such as malignancies, wound healing, and medical device implantation, we can isolate therapeutic targets for pharmacologic and bioengineered interventions.
摘要：
生物工程和药物递送技术在弥合基础科学发现和治疗临床应用之间的差距方面发挥着重要作用。为了确定最佳治疗方法，最关键的阶段是诊断问题。通常这两者可以同时或并行发生，但是在这次审查中，我们专注于自下而上的方法来理解基本的免疫学现象，以开发靶向治疗。这可以在几个领域观察到；在这里，我们将重点关注原始免疫疗法的目标之一-癌症-和最近的目标之一-再生医学。通过了解我们的免疫系统在恶性肿瘤等过程中的反应，伤口愈合，和医疗器械植入，我们可以分离药物和生物工程干预的治疗靶点.
