Abstract：
BACKGROUND: This study aims to examine the relationship between fluid overload, Vascular Endothelial Growth Factor C (VEGF-C), plasma Angiotensinogen (pAGT), and echocardiography findings in hemodialysis patients.
METHODS: This was a single-center, cross-sectional study. Patients were divided into two groups according to mid-week inter-dialytic weight gain (mIDWG): (1) mIDWG ≤3% and (2) mIDW >3%.
RESULTS: A total of 55 patients were enrolled in this study. While the mean pAGT and left ventricular mass index were significantly higher in patients with mIDWG >3% compared to patients with mIDWG ≤3%, VEGF-C was similar between groups. pAGT ≥76.8 mcg/L, VEGF-C ≤175.5 pg/ML, and pAGT /VEGF-C ≥0.45 were significant cut-offs for the prediction of left ventricular hypertrophy(LVH). Univariate logistic regression analysis revealed that these cut-off values were significantly associated with LVH.
CONCLUSIONS: Renin-angiotensin-aldosterone system activation may persist in hemodialysis patients with excessive IDWG. Additionally, pAGT and VEGF-C could be risk factors for the development of LVH.
METHODS: This was a single-center, cross-sectional study. Patients were divided into two groups according to mid-week inter-dialytic weight gain (mIDWG): (1) mIDWG ≤3% and (2) mIDW >3%.
RESULTS: A total of 55 patients were enrolled in this study. While the mean pAGT and left ventricular mass index were significantly higher in patients with mIDWG >3% compared to patients with mIDWG ≤3%, VEGF-C was similar between groups. pAGT ≥76.8 mcg/L, VEGF-C ≤175.5 pg/ML, and pAGT /VEGF-C ≥0.45 were significant cut-offs for the prediction of left ventricular hypertrophy(LVH). Univariate logistic regression analysis revealed that these cut-off values were significantly associated with LVH.
CONCLUSIONS: Renin-angiotensin-aldosterone system activation may persist in hemodialysis patients with excessive IDWG. Additionally, pAGT and VEGF-C could be risk factors for the development of LVH.
摘要：
背景：这项研究旨在检查流体过载之间的关系，血管内皮生长因子C(VEGF-C),血浆血管紧张素原（pAGT），和血液透析患者的超声心动图检查结果。
方法：这是一个单中心，横断面研究。根据透析周间体重增加（mIDWG）将患者分为两组：（1）mIDWG≤3％和（2）mIDW>3％。
结果：本研究共纳入55例患者。尽管mIDWG>3％的患者的平均pAGT和左心室质量指数明显高于mIDWG≤3％的患者，各组VEGF-C相似。pAGT≥76.8mcg/L，VEGF-C≤175.5pg/ML，和pAGT/VEGF-C≥0.45是预测左心室肥厚（LVH）的重要截止值。单因素logistic回归分析显示这些临界值与LVH显著相关。
结论：肾素-血管紧张素-醛固酮系统激活可能在IDWG过量的血液透析患者中持续存在。此外,pAGT和VEGF-C可能是LVH发生的危险因素。
方法：这是一个单中心，横断面研究。根据透析周间体重增加（mIDWG）将患者分为两组：（1）mIDWG≤3％和（2）mIDW>3％。
结果：本研究共纳入55例患者。尽管mIDWG>3％的患者的平均pAGT和左心室质量指数明显高于mIDWG≤3％的患者，各组VEGF-C相似。pAGT≥76.8mcg/L，VEGF-C≤175.5pg/ML，和pAGT/VEGF-C≥0.45是预测左心室肥厚（LVH）的重要截止值。单因素logistic回归分析显示这些临界值与LVH显著相关。
结论：肾素-血管紧张素-醛固酮系统激活可能在IDWG过量的血液透析患者中持续存在。此外,pAGT和VEGF-C可能是LVH发生的危险因素。
