PDF(Pubmed)
Abstract：
Titanium (Ti), as a hard tissue implant, is facing a big challenge for rapid and stable osseointegration owing to its intrinsic bio-inertness. Meanwile, surface-related infection is also a serious threat. In this study, large-scale quasi-vertically aligned sodium titanate nanowire (SNW) arrayed coatings incorporated with bioactive Cu2+ ions were fabricated through a compound process involving acid etching, hydrothermal treatment (HT), and ion exchange (IE). A novel coating based on sustained ion release and a shape-preserving design is successfully obtained. Cu2+ substituted Na+ in sodium titanate lattice to generate Cu-doped SNW (CNW), which maintains the micro-structure and phase components of the original SNW, and can be efficiently released from the structure by immersing them in physiological saline (PS) solutions, ensuring superior long-term structural stability. The synergistic effects of the acid etching, bidirectional cogrowth, and solution-strengthening mechanisms endow the coating with higher bonding strengths. In vitro antibacterial tests demonstrated that the CNW coatings exhibited effective good antibacterial properties against both Gram-positive and Gram-negative bacteria based on the continuous slow release of copper ions. This is an exciting attempt to achieve topographic, hydrophilic, and antibacterial activation of metal implants, demonstrating a paradigm for the activation of coatings without dissolution and providing new insights into insoluble ceramic-coated implants with high bonding strengths.
摘要：
钛(Ti),作为硬组织植入物，由于其固有的生物惰性，其快速稳定的骨整合面临着巨大的挑战。Meanwile,表面相关的感染也是一个严重的威胁。在这项研究中,大规模准垂直排列的钛酸钠纳米线（SNW）阵列的涂层结合生物活性Cu2+离子是通过涉及酸蚀刻的复合工艺制造，水热处理（HT），和离子交换（IE）。成功获得了一种基于持续离子释放和形状保持设计的新型涂层。钛酸钠晶格中Cu2+取代Na+生成Cu掺杂SNW(CNW),保持原始SNW的微观结构和相成分，并且可以通过将它们浸入生理盐水（PS）溶液中有效地从结构中释放，确保卓越的长期结构稳定性。酸蚀刻的协同效应，双向共生长，和溶液强化机制赋予涂层更高的结合强度。体外抗菌测试表明，基于铜离子的持续缓慢释放，CNW涂层对革兰氏阳性和革兰氏阴性细菌均表现出有效的良好抗菌性能。这是一个令人兴奋的尝试，以实现地形，亲水性,和金属植入物的抗菌活化，展示了激活涂层而不溶解的范例，并为具有高粘合强度的不溶性陶瓷涂层植入物提供了新的见解。
