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Abstract：
Knee osteoarthritis (KOA) is a chronic degenerative disease characterized by progressive joint damage leading to significant disability. Although rehabilitative treatment methods for KOA have been widely implemented, the optimal integrated instrumental physical therapy approach remains unclear. Therefore, this study aimed to analyze the effect of Quantum Molecular Resonance (QMR) on pain reduction as the primary outcome and the functional improvement in activity daily living (ADL) as a secondary outcome. The study was designed as a double-blind, randomized, controlled trial in an outpatient setting. Fifty-four (N = 54) patients were enrolled and then randomized into three groups according to a simple randomization list: Group 1 (intensive protocol, N = 22), Group 2 (extensive protocol, N = 21), and a Sham group (N = 11). Patients were evaluated over time with scales assessing pain and function. Treatment was performed with the QMR model electro-medical device, which generates alternating electric currents characterized by high frequency (4-64 MHz). The results showed that QMR had a positive effect with respect to the Sham group in terms of pain and function (p < 0.01), and intensive treatment was more effective than the extensive treatment in terms of \"speed of response\" to the treatment (p < 0.05). In conclusion, QMR in KOA could be effective in slowing the progression of clinical symptoms and improving patients\' pain and functionality and thus quality of life. Future studies will be necessary to investigate further treatment algorithms and therapeutic associations with rehabilitative exercise.
摘要：
膝骨关节炎(KOA)是一种慢性退行性疾病,其特征在于进行性关节损伤导致显著残疾。尽管KOA的康复治疗方法已得到广泛实施，最佳的综合仪器物理治疗方法仍不清楚.因此,本研究旨在分析量子分子共振(QMR)对作为主要结局的疼痛减轻和作为次要结局的日常生活活动能力(ADL)功能改善的影响.这项研究被设计成双盲，随机化，门诊对照试验。纳入54例（N=54）患者，然后根据简单的随机化列表随机分为三组：第1组（强化方案，N=22),第二组(广泛的协议，N=21),和Sham组(N=11)。随着时间的推移，用评估疼痛和功能的量表对患者进行评估。使用QMR模型电医疗设备进行治疗，产生以高频（4-64MHz）为特征的交流电流。结果表明，QMR在疼痛和功能方面对Sham组具有积极作用（p<0.01），在对治疗的“反应速度”方面，强化治疗比广泛治疗更有效（p<0.05）。总之,QMR治疗KOA可有效减缓临床症状进展，改善患者疼痛和功能，从而提高生活质量。未来的研究将是必要的，以研究进一步的治疗算法和与康复运动的治疗关联。
