PDF(Pubmed)
Abstract：
BACKGROUND: This study aims to evaluate maternal reassurance, satisfaction, and anxiety after two different strategies for the first-trimester screening for aneuploidies.
METHODS: Patients between 11 + 3 and 13 + 6 weeks of gestation attending the first-trimester screening at Department of Mother and Child, University Hospital Federico II, Naples, Italy have been recruited and randomly allocated to contingent screening or universal cell-free fetal DNA testing (cffDNA). Questionnaires to measure reassurance, satisfaction, and anxiety have been filled twice: (Q1) after randomization and (Q2) after receiving results. Anxiety was measured by an Italian-version short form of the state scale of the Spielberger State-Trait Anxiety Inventory (STAI); child-related anxiety was measured by the 11-item Pregnancy-Related Anxiety Questionnaire-Revised Regardless of Parity (PRAQ-R2 scale); fear of bearing a physically or mentally handicapped child was measured considering only four items (item 4, 9, 10, and 11) of the PRAQ-R2 scale.
RESULTS: 431 patients were recruited: 205 (49%) were randomized in the contingent screening arm, 226 (51%) in the cfDNA arm. Maternal reassurance, satisfaction, and anxiety were not different in the two groups.
CONCLUSIONS: A contingent screening for aneuploidies in the first trimester seems able to ensure the same maternal reassurance and satisfaction as a cfDNA analysis in the low-risk population and to not affect maternal anxiety.
METHODS: Patients between 11 + 3 and 13 + 6 weeks of gestation attending the first-trimester screening at Department of Mother and Child, University Hospital Federico II, Naples, Italy have been recruited and randomly allocated to contingent screening or universal cell-free fetal DNA testing (cffDNA). Questionnaires to measure reassurance, satisfaction, and anxiety have been filled twice: (Q1) after randomization and (Q2) after receiving results. Anxiety was measured by an Italian-version short form of the state scale of the Spielberger State-Trait Anxiety Inventory (STAI); child-related anxiety was measured by the 11-item Pregnancy-Related Anxiety Questionnaire-Revised Regardless of Parity (PRAQ-R2 scale); fear of bearing a physically or mentally handicapped child was measured considering only four items (item 4, 9, 10, and 11) of the PRAQ-R2 scale.
RESULTS: 431 patients were recruited: 205 (49%) were randomized in the contingent screening arm, 226 (51%) in the cfDNA arm. Maternal reassurance, satisfaction, and anxiety were not different in the two groups.
CONCLUSIONS: A contingent screening for aneuploidies in the first trimester seems able to ensure the same maternal reassurance and satisfaction as a cfDNA analysis in the low-risk population and to not affect maternal anxiety.
摘要：
背景：这项研究旨在评估产妇的保证，满意,在进行非整倍体筛查的两种不同策略后，以及焦虑。
方法：妊娠11+3至13+6周的患者在母婴科进行孕早期筛查，FedericoII大学医院,那不勒斯,意大利已被招募并随机分配到临时筛查或通用无细胞胎儿DNA测试（cffDNA）。问卷调查来衡量安慰，满意,和焦虑已经填补了两次：（Q1）随机分组后和（Q2）收到结果后。焦虑是通过Spielberger状态-特质焦虑量表（STAI）的状态量表的意大利语版本的简短形式来衡量的；与儿童相关的焦虑是通过11项妊娠相关的焦虑问卷（PRAQ-R2量表）进行测量的；仅考虑了四个项目（PRAQ量表的第4、9、10和11项）来衡量与身体或智障儿童的恐惧。
结果：招募了431名患者：205（49％）在特遣队筛查组中随机分配，226(51%)在cfDNA臂中。产妇放心，满意,焦虑在两组中没有差异。
结论：孕早期非整倍体筛查似乎能够确保低危人群中与cfDNA分析相同的产妇保证和满意度，并且不会影响产妇焦虑。
方法：妊娠11+3至13+6周的患者在母婴科进行孕早期筛查，FedericoII大学医院,那不勒斯,意大利已被招募并随机分配到临时筛查或通用无细胞胎儿DNA测试（cffDNA）。问卷调查来衡量安慰，满意,和焦虑已经填补了两次：（Q1）随机分组后和（Q2）收到结果后。焦虑是通过Spielberger状态-特质焦虑量表（STAI）的状态量表的意大利语版本的简短形式来衡量的；与儿童相关的焦虑是通过11项妊娠相关的焦虑问卷（PRAQ-R2量表）进行测量的；仅考虑了四个项目（PRAQ量表的第4、9、10和11项）来衡量与身体或智障儿童的恐惧。
结果：招募了431名患者：205（49％）在特遣队筛查组中随机分配，226(51%)在cfDNA臂中。产妇放心，满意,焦虑在两组中没有差异。
结论：孕早期非整倍体筛查似乎能够确保低危人群中与cfDNA分析相同的产妇保证和满意度，并且不会影响产妇焦虑。
