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Abstract：
BACKGROUND: Malignant pleural effusion (MPE) affects up to 15% of patients with malignancy, and the prevalence is increasing. Non-expandable lung (NEL) complicates MPE in up to 30% of cases. However, it is not known if patients with malignant pleural effusion and NEL are more symptomatic in activities of daily living compared to patients with MPE with expandable lung.
METHODS: This was an observational study on consecutively recruited patients with MPE from our pleural clinic. Before thoracentesis, patients completed patient-reported outcomes on cancer symptoms (ESAS), health-related quality of life (5Q-5D-5L), and dyspnoea scores. Following thoracentesis, patients scored dyspnoea relief and symptoms during thoracentesis. Data on focused lung ultrasound and pleural effusion biochemistry were collected. The non-expandable lung diagnosis was made by pleural experts based on radiological and clinical information.
RESULTS: We recruited 43 patients, including 12 with NEL (28%). The NEL cohort resembled those from previous studies concerning ultrasonography, pleural fluid biochemistry, and fewer cases with high volume thoracentesis. Patients with and without NEL were comparable concerning baseline demography. The 5Q-5D-5L utility scores were 0.836 (0.691-0.906) and 0.806 (0.409-0.866), respectively, for patients with and without NEL. We observed no between-group differences in symptom burden or health-related quality of life.
CONCLUSIONS: While the presence of NEL affects the clinical management of recurrent MPE, the presence of NEL seems not to affect patients\' overall symptom burden in patients with MPE.
METHODS: This was an observational study on consecutively recruited patients with MPE from our pleural clinic. Before thoracentesis, patients completed patient-reported outcomes on cancer symptoms (ESAS), health-related quality of life (5Q-5D-5L), and dyspnoea scores. Following thoracentesis, patients scored dyspnoea relief and symptoms during thoracentesis. Data on focused lung ultrasound and pleural effusion biochemistry were collected. The non-expandable lung diagnosis was made by pleural experts based on radiological and clinical information.
RESULTS: We recruited 43 patients, including 12 with NEL (28%). The NEL cohort resembled those from previous studies concerning ultrasonography, pleural fluid biochemistry, and fewer cases with high volume thoracentesis. Patients with and without NEL were comparable concerning baseline demography. The 5Q-5D-5L utility scores were 0.836 (0.691-0.906) and 0.806 (0.409-0.866), respectively, for patients with and without NEL. We observed no between-group differences in symptom burden or health-related quality of life.
CONCLUSIONS: While the presence of NEL affects the clinical management of recurrent MPE, the presence of NEL seems not to affect patients\' overall symptom burden in patients with MPE.
摘要：
背景：恶性胸腔积液（MPE）影响多达15％的恶性肿瘤患者，患病率正在增加。在高达30%的病例中,非膨胀型肺(NEL)使MPE复杂化。然而,目前尚不清楚恶性胸腔积液和NEL患者是否比MPE患者的日常生活活动更有症状。
方法：这是一项对我们胸膜诊所连续招募的MPE患者的观察性研究。胸腔穿刺术前,患者完成了患者报告的癌症症状结果（ESAS），健康相关生活质量（5Q-5D-5L），和呼吸困难评分。胸腔穿刺术后,患者在胸腔穿刺术中呼吸困难缓解和症状评分。收集聚焦肺超声和胸腔积液生化数据。非扩张肺诊断由胸膜专家根据放射学和临床信息做出。
结果：我们招募了43名患者，包括12个NEL（28％）。NEL队列类似于先前关于超声检查的研究，胸膜液生物化学，大量胸腔穿刺术的病例较少。有和没有NEL的患者在基线人口统计学方面具有可比性。5Q-5D-5L效用得分分别为0.836(0.691-0.906)和0.806(0.409-0.866),分别,对于有和没有NEL的患者。我们没有观察到症状负担或健康相关生活质量的组间差异。
结论：虽然NEL的存在会影响复发性MPE的临床治疗，NEL的存在似乎不会影响MPE患者的总体症状负担。
方法：这是一项对我们胸膜诊所连续招募的MPE患者的观察性研究。胸腔穿刺术前,患者完成了患者报告的癌症症状结果（ESAS），健康相关生活质量（5Q-5D-5L），和呼吸困难评分。胸腔穿刺术后,患者在胸腔穿刺术中呼吸困难缓解和症状评分。收集聚焦肺超声和胸腔积液生化数据。非扩张肺诊断由胸膜专家根据放射学和临床信息做出。
结果：我们招募了43名患者，包括12个NEL（28％）。NEL队列类似于先前关于超声检查的研究，胸膜液生物化学，大量胸腔穿刺术的病例较少。有和没有NEL的患者在基线人口统计学方面具有可比性。5Q-5D-5L效用得分分别为0.836(0.691-0.906)和0.806(0.409-0.866),分别,对于有和没有NEL的患者。我们没有观察到症状负担或健康相关生活质量的组间差异。
结论：虽然NEL的存在会影响复发性MPE的临床治疗，NEL的存在似乎不会影响MPE患者的总体症状负担。
