PDF(Pubmed)
Abstract：
Hyperglycemia and pulmonary hypertension (PH) share common pathological pathways that lead to vascular dysfunction and resultant cardiovascular complications. These shared pathologic pathways involve endothelial dysfunction, inflammation, oxidative stress, and hormonal imbalances. Individuals with hyperglycemia or pulmonary hypertension also possess shared clinical factors that contribute to increased morbidity from both diseases. This review aims to explore the relationship between PH and hyperglycemia, highlighting the mechanisms underlying their association and discussing the clinical implications. Understanding these common pathologic and clinical factors will enable early detection for those at-risk for complications from both diseases, paving the way for improved research and targeted therapeutics.
摘要：
高血糖和肺动脉高压(PH)共有共同的病理途径,其导致血管功能障碍和由此产生的心血管并发症。这些共同的病理通路涉及内皮功能障碍，炎症,氧化应激，荷尔蒙失衡。患有高血糖症或肺动脉高压的个体也具有共同的临床因素,这些因素有助于增加两种疾病的发病率。本文旨在探讨PH与高血糖的关系,强调其关联的潜在机制并讨论其临床意义。了解这些常见的病理和临床因素将有助于早期发现这两种疾病并发症的风险。为改进研究和靶向治疗铺平了道路。
