PDF(Pubmed)
Abstract：
Chronic kidney disease (CKD) presents a formidable global health concern, affecting one in six adults over 25. This review explores the potential of phenolic compounds in managing CKD and its complications. By examining the existing research, we highlight their diverse biological activities and potential to combat CKD-related issues. We analyze the nutritional benefits, bioavailability, and safety profile of these compounds. While the clinical evidence is promising, preclinical studies offer valuable insights into underlying mechanisms, optimal dosages, and potential side effects. Further research is crucial to validate the therapeutic efficacy of phenolic compounds for CKD. We advocate for continued exploration of their innovative applications in food, pharmaceuticals, and nutraceuticals. This review aims to catalyze the scientific community\'s efforts to leverage phenolic compounds against CKD-related challenges.
摘要：
慢性肾脏病（CKD）提出了一个巨大的全球健康问题，影响六分之一25岁以上的成年人。这篇综述探讨了酚类化合物在治疗CKD及其并发症中的潜力。通过考察现有的研究，我们强调其多样化的生物活性和对抗CKD相关问题的潜力。我们分析营养益处，生物利用度，以及这些化合物的安全性。虽然临床证据很有希望，临床前研究提供了对潜在机制的有价值的见解，最佳剂量，和潜在的副作用。进一步的研究对于验证酚类化合物对CKD的治疗效果至关重要。我们主张继续探索它们在食品中的创新应用，制药，和营养食品。这篇综述旨在促进科学界利用酚类化合物对抗CKD相关挑战的努力。
