PDF(Pubmed)
Abstract：
In this study, we designed a novel electrochemical sensor by modifying a glass carbon electrode (GCE) with Pd confined mesoporous carbon hollow nanospheres (Pd/MCHS) for the simultaneous detection of ascorbic acid (AA), dopamine (DA), and uric acid (UA). The structure and morphological characteristics of the Pd/MCHS nanocomposite and the Pd/MCHS/GCE sensor are comprehensively examined using SEM, TEM, XRD and EDX. The electrochemical properties of the prepared sensor are investigated through CV and DPV, which reveal three resolved oxidation peaks for AA, DA, and UA, thereby verifying the simultaneous detection of the three analytes. Benefiting from its tailorable properties, the Pd/MCHS nanocomposite provides a large surface area, rapid electron transfer ability, good catalytic activity, and high conductivity with good electrochemical behavior for the determination of AA, DA, and UA. Under optimized conditions, the Pd/MCHS/GCE sensor exhibited a linear response in the concentration ranges of 300-9000, 2-50, and 20-500 µM for AA, DA, and UA, respectively. The corresponding limit of detection (LOD) values were determined to be 51.03, 0.14, and 4.96 µM, respectively. Moreover, the Pd/MCHS/GCE sensor demonstrated outstanding selectivity, reproducibility, and stability. The recovery percentages of AA, DA, and UA in real samples, including a vitamin C tablet, DA injection, and human urine, range from 99.8-110.9%, 99.04-100.45%, and 98.80-100.49%, respectively. Overall, the proposed sensor can serve as a useful reference for the construction of a high-performance electrochemical sensing platform.
摘要：
在这项研究中,我们通过用Pd限制的介孔碳中空纳米球（Pd/MCHS）修饰玻璃碳电极（GCE），设计了一种新型的电化学传感器，用于同时检测抗坏血酸（AA），多巴胺（DA），尿酸（UA）。利用SEM对Pd/MCHS纳米复合材料和Pd/MCHS/GCE传感器的结构和形态特征进行了全面的研究,TEM,XRD和EDX。通过CV和DPV研究了制备的传感器的电化学性能,揭示了AA的三个解析氧化峰，DA,UA,从而验证三种分析物的同时检测。受益于其可剪裁的属性，Pd/MCHS纳米复合材料提供了大的表面积，快速电子转移能力，良好的催化活性，和高电导率，具有良好的电化学行为，用于测定AA，DA,UA。在优化条件下，对于AA，Pd/MCHS/GCE传感器在300-9000、2-50和20-500µM的浓度范围内表现出线性响应，DA,UA,分别。相应的检测限（LOD）值被确定为51.03，0.14和4.96µM，分别。此外，Pd/MCHS/GCE传感器表现出出色的选择性，再现性，和稳定性。AA的回收率，DA,和UA在真实样本中，包括维生素C片剂，DA注射,和人类尿液，范围从99.8-110.9%，99.04-100.45%，和98.80-100.49%，分别。总的来说,该传感器可为构建高性能电化学传感平台提供参考。
