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Abstract：
BACKGROUND: Although rare, sinonasal cancers (SNCs) have a high occupational attributable fraction.
METHODS: We applied gender-based approaches to descriptive analyses, incidence, and patterns of exposures using the Italian National Sinonasal Cancer Registry (ReNaTuNS: Registro Nazionale Tumori Naso-Sinusali).
RESULTS: The study included 2851 SNC patients. SNC was diagnosed more often in men (73%) than in women (27%). The most frequent morphology in men was intestinal-type adenocarcinoma (33%), whereas in women, it was squamous cell carcinoma (49%). Nasal cavities were predominant in both genders (50%), ethmoidal sinus in men (24%), and maxillary in women (24%). Incidence rates were 0.76 (per 100,000 person-years) in men and 0.24 in women and increased by age, more evidently in men, peaking over 75 years in both. Occupational exposures to wood and leather dusts were the most frequent (41% for men, 33% for women). Few exposures were extra-occupational or domestic. Unlikely exposure was relevant in women (57%).
CONCLUSIONS: The surveillance of SNC cases through a registry that allows for the identification of and compensation for this occupational disease is important in Italy, where numerous workers are exposed to carcinogens for SNC, without even being aware. Considering the rarity of the disease, particularly among women, the ReNaTuNS can provide a method to analyze gender differences.
METHODS: We applied gender-based approaches to descriptive analyses, incidence, and patterns of exposures using the Italian National Sinonasal Cancer Registry (ReNaTuNS: Registro Nazionale Tumori Naso-Sinusali).
RESULTS: The study included 2851 SNC patients. SNC was diagnosed more often in men (73%) than in women (27%). The most frequent morphology in men was intestinal-type adenocarcinoma (33%), whereas in women, it was squamous cell carcinoma (49%). Nasal cavities were predominant in both genders (50%), ethmoidal sinus in men (24%), and maxillary in women (24%). Incidence rates were 0.76 (per 100,000 person-years) in men and 0.24 in women and increased by age, more evidently in men, peaking over 75 years in both. Occupational exposures to wood and leather dusts were the most frequent (41% for men, 33% for women). Few exposures were extra-occupational or domestic. Unlikely exposure was relevant in women (57%).
CONCLUSIONS: The surveillance of SNC cases through a registry that allows for the identification of and compensation for this occupational disease is important in Italy, where numerous workers are exposed to carcinogens for SNC, without even being aware. Considering the rarity of the disease, particularly among women, the ReNaTuNS can provide a method to analyze gender differences.
摘要：
背景：虽然罕见，鼻窦肿瘤（SNCs）具有较高的职业归因分数。
方法：我们将基于性别的方法应用于描述性分析，发病率,和使用意大利国家鼻窦癌症登记处（ReNaTuNS：RegistroNazionaleTumoriNaso-Sinusali）的暴露模式。
结果：该研究包括2851名SNC患者。男性（73％）比女性（27％）更容易被诊断出SNC。男性最常见的形态学是肠型腺癌（33%），而在女性中，它是鳞状细胞癌（49％）。两种性别都以鼻腔为主（50%），男性的筛窦（24％），和上颌女性（24％）。男性发病率为0.76（每100,000人年），女性为0.24，按年龄增长，更明显的是在男人身上，两者都达到了75年的顶峰。职业接触木材和皮革灰尘的频率最高(男性为41%，33%为女性）。很少有暴露是职业外或家庭的。不太可能的暴露与女性有关（57％）。
结论：在意大利，通过允许识别和赔偿这种职业病的登记处对SNC病例进行监测很重要，许多工人接触SNC的致癌物，甚至没有意识到。考虑到这种疾病的稀有性,尤其是在女性中，ReNaTuNS可以提供一种分析性别差异的方法。
方法：我们将基于性别的方法应用于描述性分析，发病率,和使用意大利国家鼻窦癌症登记处（ReNaTuNS：RegistroNazionaleTumoriNaso-Sinusali）的暴露模式。
结果：该研究包括2851名SNC患者。男性（73％）比女性（27％）更容易被诊断出SNC。男性最常见的形态学是肠型腺癌（33%），而在女性中，它是鳞状细胞癌（49％）。两种性别都以鼻腔为主（50%），男性的筛窦（24％），和上颌女性（24％）。男性发病率为0.76（每100,000人年），女性为0.24，按年龄增长，更明显的是在男人身上，两者都达到了75年的顶峰。职业接触木材和皮革灰尘的频率最高(男性为41%，33%为女性）。很少有暴露是职业外或家庭的。不太可能的暴露与女性有关（57％）。
结论：在意大利，通过允许识别和赔偿这种职业病的登记处对SNC病例进行监测很重要，许多工人接触SNC的致癌物，甚至没有意识到。考虑到这种疾病的稀有性,尤其是在女性中，ReNaTuNS可以提供一种分析性别差异的方法。
