PDF(Pubmed)
Abstract：
Introduction: HIV is a severe and incurable disease that has a devastating impact worldwide. It affects the immune system and negatively affects the nervous system, leading to various cognitive and behavioral problems. Scientists are actively exploring different therapeutic approaches to combat these issues. One promising method is transcranial direct current stimulation (tDCS), a non-invasive technique that stimulates the brain. Methods: This review aims to examine how tDCS can help HIV patients. Searches were conducted in the Pubmed/Medline, Research Gate, and Cochrane databases. Results: The literature search resulted in six articles focusing on the effects of tDCS on cognitive and behavioral measures in people with HIV. In some cases, tDCS showed positive improvements in the measures assessed, improving executive functions, depression, attention, reaction time, psychomotor speed, speed of processing, verbal learning and memory, and cognitive functioning. Furthermore, the stimulation was safe with no severe side effects. However, the included studies were of low quality, had small sample sizes, and did not use any relevant biomarkers that would help to understand the mechanisms of action of tDCS in HIV. Conclusions: tDCS may help patients with HIV; however, due to the limited number of studies and the diversity of protocols used, caution should be exercised when recommending this treatment option in clinical settings. More high-quality research, preferably involving neurophysiological and neuroimaging measurements, is necessary to better understand how tDCS works in individuals with HIV.
摘要：
简介：艾滋病毒是一种严重且无法治愈的疾病，在全球范围内具有破坏性影响。它会影响免疫系统并对神经系统产生负面影响，导致各种认知和行为问题。科学家们正在积极探索不同的治疗方法来解决这些问题。一种有前途的方法是经颅直流电刺激（tDCS），一种刺激大脑的非侵入性技术。方法：这篇综述旨在研究tDCS如何帮助HIV患者。搜索在Pubmed/Medline中进行，研究门,和Cochrane数据库。结果：文献检索产生了六篇文章，重点研究了tDCS对HIV感染者的认知和行为措施的影响。在某些情况下,tDCS在评估的措施中显示出积极的改善，改善执行职能，抑郁症,注意,反应时间,精神运动速度，处理速度,口头学习和记忆，和认知功能。此外，刺激是安全的,无严重副作用.然而,纳入的研究质量低，样本量小，并且没有使用任何有助于理解tDCS在HIV中的作用机制的相关生物标志物。结论：tDCS可以帮助HIV患者；然而，由于研究的数量有限和使用的协议的多样性，在临床上推荐这种治疗方案时应谨慎行事。更多高质量的研究，优选涉及神经生理学和神经影像学测量，有必要更好地了解tDCS如何在艾滋病毒感染者中发挥作用。
