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Abstract：
Background: Erectile dysfunction (ED) most often has vascular etiology and usually is the earliest symptom of vascular dysfunction. The aim of this study was to evaluate vascular dysfunction with the use of the Flow-Mediated Skin Fluorescence (FMSF) technique in men with and without ED. Methods: Included were 39 men (median age 53) with ED and 40 men (median age 41.5) without ED. Medical interview, physical examination, and anthropometrical measurements were performed for all participants. The serum total testosterone, LH, and SHBG determinations were performed in patients with ED, and the Free Testosterone Index (FTI) was calculated. The FMSF technique was used to measure the microcirculatory oscillations at the baseline and to determine the flowmotion (FM) and vasomotion (VM) parameters. The Normoxia Oscillatory Index (NOI) was calculated, which represents the contribution of the endothelial (ENDO) and neurogenic (NEURO) oscillations relative to all oscillations detected at low-frequency intervals (<0.15 Hz): NOI = (ENDO + NEURO)/(ENDO + NEURO + VM). Results: In men with ED were found significantly lower FM and VM parameters, but the NOI was significantly higher in comparison to men without ED. VM and FM correlated significantly positively with erectile function, orgasmic function, and general sexual satisfaction in the whole group and the FTI in the ED group. The thresholds of 53.5 FM (AUC = 0.7) and 8.4 VM (AUC = 0.7) were predictive values for discriminating men with ED. Conclusions: It was shown that the FMSF diagnostic technique may be helpful in the early diagnosis of microcirculation dysfunction due to impaired vasomotion caused by decreased testosterone activity.
摘要：
背景：勃起功能障碍（ED）最常见的是血管病因，通常是血管功能障碍的最早症状。这项研究的目的是使用血流介导的皮肤荧光（FMSF）技术评估有和没有ED的男性的血管功能障碍。方法：包括39名患有ED的男性（中位年龄53）和40名没有ED的男性（中位年龄41.5）。医学访谈,体检,并对所有参与者进行人体测量.血清总睾酮,LH,对ED患者进行SHBG测定，计算游离睾酮指数(FTI)。FMSF技术用于测量基线处的微循环振荡并确定流动运动（FM）和血管舒缩（VM）参数。计算了常氧振荡指数(NOI)，其表示内皮(ENDO)和神经源性(NEURO)振荡相对于在低频间隔(<0.15Hz)检测到的所有振荡的贡献:NOI=(ENDO+NEURO)/(ENDO+NEURO+VM)。结果：在男性ED患者中，发现FM和VM参数显着降低，但与没有ED的男性相比，NOI明显更高。VM和FM与勃起功能呈显著正相关，性高潮功能,全组的一般性满意度和ED组的FTI。53.5FM（AUC=0.7）和8.4VM（AUC=0.7）的阈值是区分ED男性的预测值。结论：FMSF诊断技术可能有助于早期诊断由于睾酮活性降低引起的血管舒缩受损而导致的微循环功能障碍。
