PDF(Pubmed)
Abstract：
We developed a system to adjust the rate of a continuous rocuronium (Rb) infusion to achieve 3 ≤ %T1 ≤ 10 with a closed-loop control. Samples were collected from 15 patients, and Rb blood concentrations were measured at the following time points: (1) when %T1 recovered to 3% or more after the initial Rb infusion; (2) when %T1 stabilized within the target range; (3) at the cessation of the Rb infusion; (4) 5 min after the sugammadex administration. The predicted Rb blood concentration at each time point was calculated and recorded using the pharmacokinetic parameters of Wierda et al. At time points (1), (2), and (3), the predicted blood concentrations were in good agreement with the measured values, but after the administration of sugammadex, the blood concentrations were higher than the predicted values because the Rb distributed in the tissues migrated into the blood. From the above, it was confirmed that the predicted blood concentration of Rb can be a good indicator for the automatic Rb administration control.
摘要：
我们开发了一种系统，可以通过闭环控制来调节连续罗库溴铵（Rb）输注的速率，以实现3≤％T1≤10。收集了15名患者的样本，和Rb血液浓度在以下时间点测量:(1)当%T1在初始Rb输注后恢复到3%或更高时;(2)当%T1稳定在目标范围内时;(3)在Rb输注停止时;(4)在sugammadex施用后5分钟。使用Wierda等人的药代动力学参数计算并记录每个时间点的预测Rb血液浓度。在时间点（1），(2),（3）、预测的血液浓度与测量值吻合良好，但是在sugammadex管理之后，血液浓度高于预测值，因为分布在组织中的Rb迁移到血液中。从上面来看,证实了Rb的预测血药浓度可以是自动Rb给药控制的良好指标。
