PDF(Pubmed)
Abstract：
Background: Vestibular schwannoma (VS) is a benign tumor of the eighth cranial nerve formed from neoplastic Schwann cells. Although VS can cause a variety of symptoms, tinnitus is one of the most distressing symptoms for patients and can greatly impact quality of life. The objective of this systematic review is to comprehensively examine and compare the outcomes related to tinnitus in patients undergoing treatment for VS. Specifically, it evaluates patient experiences with tinnitus following the removal of VS using the various surgical approaches of traditional surgical resection and gamma knife radiosurgery (GKS). By delving into various aspects such as the severity of tinnitus post-treatment, the duration of symptom relief, patient quality of life, new onset of tinnitus after VS treatment, and any potential complications or side effects, this review aims to provide a detailed analysis of VS treatment on tinnitus outcomes. Methods: Following PRISMA guidelines, articles were included from PubMed, Science Direct, Scopus, and EMBASE. Quality assessment and risk of bias analysis were performed using a ROBINS-I tool. Results: Although VS-associated tinnitus is variable in its intensity and persistence post-resection, there was a trend towards a decreased tinnitus burden in patients. Irrespective of the surgical approach or the treatment with GKS, there were cases of persistent or worsened tinnitus within the studied cohorts. Conclusion: The findings of this systematic review highlight the complex relationship between VS resection and tinnitus outcomes. These findings underscore the need for individualized patient counseling and tailored treatment approaches in managing VS-associated tinnitus. The findings of this systematic review may help in guiding clinicians towards making more informed and personalized healthcare decisions. Further studies must be completed to fill gaps in the current literature.
摘要：
背景：前庭神经鞘瘤（VS）是由肿瘤雪旺细胞形成的第八脑神经良性肿瘤。虽然VS可以引起各种症状，耳鸣是患者最痛苦的症状之一，会极大地影响生活质量。本系统评价的目的是全面检查和比较接受VS治疗的患者与耳鸣相关的结果。具体来说,它使用传统手术切除和伽玛刀放射外科（GKS）的各种手术方法评估VS切除后患者的耳鸣经历。通过深入研究治疗后耳鸣的严重程度等各个方面，症状缓解的持续时间，患者生活质量,VS治疗后新发耳鸣，以及任何潜在的并发症或副作用，这篇综述旨在提供VS治疗对耳鸣结局的详细分析。方法：遵循PRISMA指南，文章来自PubMed，科学直接，Scopus,和EMBASE。使用ROBINS-I工具进行质量评估和偏倚风险分析。结果：尽管VS相关的耳鸣在切除后的强度和持续性是可变的，患者的耳鸣负担有下降的趋势.无论手术方法或GKS治疗，研究队列中有持续或恶化的耳鸣病例.结论：本系统评价的结果强调了VS切除与耳鸣结局之间的复杂关系。这些发现强调了在管理VS相关耳鸣时需要个性化的患者咨询和量身定制的治疗方法。本系统评价的结果可能有助于指导临床医生做出更明智和个性化的医疗决策。必须完成进一步的研究以填补当前文献中的空白。
