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Abstract：
Background: The risk of impaired bone-pin interface strength in titanium (Ti) pins coated with fibroblast growth factor (FGF)-calcium phosphate (CP) composite layers is yet to be evaluated in a clinical study. This retrospective study used Weibull plot analysis to evaluate bone-pin interface strength in Ti pins coated with FGF-CP layers for external distal radius fracture fixation. Methods: The distal radial fractures were treated with external fixation. The FGF-CP group comprised five patients (all women, aged 70.4 ± 5.9 (range: 62-77) years), and the uncoated pin group comprised ten patients (eight women and two men, aged 64.4 ± 11.7 (range: 43-83) years). The pins were removed after six weeks. The insertion and extraction peak torques were measured. The extraction peak torque was evaluated using Weibull plot analysis. Results: We compared the extraction torque of the two groups at or below 506 Nmm for a fair comparison using Weibull plot analysis. The Weibull plots were linear for both the FGF-CP and uncoated pin groups. The slope of the regression line was significantly higher in the FGF-CP group (1.7343) than in the uncoated pin group (1.5670) (p = 0.011). The intercept of the regression line was significantly lower in the FGF-CP group (-9.847) than in the uncoated pin group (-8.708) (p = 0.002). Thus, the two regression lines significantly differed. Conclusions: Ti pins coated with FGF-CP layers exhibit the potential to reduce the risk of impaired bone-pin interface strength in the external fixation of distal radius fractures.
摘要：
背景：在临床研究中，尚未评估涂有成纤维细胞生长因子（FGF）-磷酸钙（CP）复合层的钛（Ti）针中骨-针界面强度受损的风险。这项回顾性研究使用Weibull图分析来评估涂有FGF-CP层的Ti针中用于桡骨远端骨折外固定的骨-针界面强度。方法:采用外固定支架治疗桡骨远端骨折。FGF-CP组包括5名患者(所有女性，年龄70.4±5.9（范围：62-77岁），无涂层针组包括10名患者(8名女性和2名男性，年龄64.4±11.7（范围：43-83）岁）。在六周后移除销。测量插入和提取峰值扭矩。使用Weibull图分析评估提取峰值扭矩。结果：我们使用Weibull图分析比较了两组在506Nmm以下的提取扭矩，以进行比较。对于FGF-CP和未涂覆的pin组,Weibull图都是线性的。FGF-CP组（1.7343）的回归线斜率明显高于未涂覆针组（1.5670）（p=0.011）。FGF-CP组(-9.847)的回归线的截距显著低于未涂覆针组(-8.708)(p=0.002)。因此，两条回归线明显不同。结论：涂有FGF-CP层的Ti针在桡骨远端骨折的外固定中具有降低骨-针界面强度受损的风险的潜力。
