PDF(Pubmed)
Abstract：
Sleep disorders associated with lifestyle changes and unhealthy habits are major public health concerns. Our previous study showed that Bifidobacterium adolescentis SBT2786 has a potent sleep-promoting effect on fruit flies. Fruit flies share many similarities with mammals, making them suitable model organisms for studying sleep. Thus, in the present study, we conducted a randomized, double-blind, placebo-controlled clinical trial to test whether SBT2786 has sleep-enhancing effects in humans. In this study, 61 participants in the SBT2786 group and 65 participants in the placebo group were analyzed. The results showed that SBT2786 increased sleep time; however, it predominantly increased light sleep and did not improve subjective sleep quality. Interestingly, mood improvement was observed. A subgroup analysis was conducted on participants with high stress levels, and results showed that these participants experienced an increase in sleep duration and an improvement in sleepiness upon waking up and reported feeling well-rested during the day. We concluded that SBT2786 may improve sleep quality, particularly in individuals experiencing high levels of stress, and that SBT2786 can be used as a dietary supplement to improve sleep and mood.
摘要：
与生活方式改变和不健康习惯相关的睡眠障碍是主要的公共卫生问题。我们先前的研究表明，青春期双歧杆菌SBT2786对果蝇具有有效的睡眠促进作用。果蝇与哺乳动物有许多相似之处，使它们成为研究睡眠的合适模型生物。因此，在本研究中，我们进行了一个随机的，双盲,安慰剂对照临床试验，以测试SBT2786是否对人类有睡眠增强作用。在这项研究中,分析了SBT2786组的61名参与者和安慰剂组的65名参与者。结果表明，SBT2786增加了睡眠时间；然而，它主要增加了轻度睡眠，并且没有改善主观睡眠质量。有趣的是,观察到情绪改善。对高压力水平的参与者进行了亚组分析，结果显示，这些参与者在醒来后睡眠时间增加，嗜睡改善，并报告白天休息良好。我们的结论是SBT2786可以改善睡眠质量，特别是在经历高度压力的个体中，SBT2786可以用作膳食补充剂来改善睡眠和情绪。
