PDF(Pubmed)
Abstract：
(1) Background: Irritable bowel syndrome (IBS) is a common disease in the gastrointestinal (GI) tract. Atractylodes macrocephala Koidz (AMK) is known as one of the traditional medicines that shows a good efficacy in the GI tract. (2) Methods: We investigated the effect of AMK in a network pharmacology and zymosan-induced IBS animal model. In addition, we performed electrophysiological experiments to confirm the regulatory mechanisms related to IBS. (3) Results: Various characteristics of AMK were investigated using TCMSP data and various analysis systems. AMK restored the macroscopic changes and weight to normal. Colonic mucosa and inflammatory factors were reduced. These effects were similar to those of amitriptyline and sulfasalazine. In addition, transient receptor potential (TRP) V1, voltage-gated Na+ (NaV) 1.5, and NaV1.7 channels were inhibited. (4) Conclusion: These results suggest that AMK may be a promising therapeutic candidate for IBS management through the regulation of ion channels.
摘要：
（1）背景：肠易激综合征（IBS）是胃肠道（GI）的常见疾病。白术（AMK）被认为是在胃肠道中显示出良好疗效的传统药物之一。（2）方法：我们研究了AMK在网络药理学和酵母聚糖诱导的IBS动物模型中的作用。此外,我们进行了电生理实验以确认与IBS相关的调节机制.（3）结果：使用TCMSP数据和各种分析系统研究了AMK的各种特征。AMK将宏观变化和体重恢复到正常。结肠黏膜及炎性因子均降低。这些作用与阿米替林和柳氮磺吡啶的作用相似。此外,瞬时受体电位（TRP）V1，电压门控Na（NaV）1.5和NaV1.7通道被抑制。（4）结论：这些结果表明，通过调节离子通道，AMK可能是IBS治疗的有希望的候选药物。
