PDF(Pubmed)
Abstract：
Propolis has potential anti-inflammatory properties, but little is known about its efficacy against inflammatory reactions caused by drug-resistant bacteria, and the difference in efficacy between propolis and tree gum is also unclear. Here, an in vivo study was performed to study the effects of ethanol extract from poplar propolis (EEP) and poplar tree gum (EEG) against heat-inactivated methicillin-resistant Staphylococcus aureus (MRSA)-induced acute lung injury (ALI) in mice. Pre-treatment with EEP and EEG (100 mg/kg, p.o.) resulted in significant protective effects on ALI in mice, and EEP exerted stronger activity to alleviate lung tissue lesions and ALI scores compared with that of EEG. Furthermore, EEP significantly suppressed the levels of pro-inflammatory mediators in the lung, including TNF-α, IL-1β, IL-6, and IFN-γ. Gut microbiota analysis revealed that both EEP and EEG could modulate the composition of the gut microbiota, enhance the abundance of beneficial microbiota and reduce the harmful ones, and partly restore the levels of short-chain fatty acids. EEP could modulate more serum metabolites and showed a more robust correlation between serum metabolites and gut microbiota. Overall, these results support the anti-inflammatory effects of propolis in the treatment of ALI, and the necessity of the quality control of propolis.
摘要：
蜂胶具有潜在的抗炎特性，但是对其对抗耐药细菌引起的炎症反应的功效知之甚少，蜂胶和树胶的功效差异也不清楚。这里,进行了一项体内研究，以研究杨树蜂胶（EEP）和杨树胶（EEG）的乙醇提取物对热灭活的耐甲氧西林金黄色葡萄球菌（MRSA）引起的小鼠急性肺损伤（ALI）的影响。EEP和EEG预处理（100mg/kg，p.o.）对小鼠ALI产生了显着的保护作用，与EEG相比，EEP对减轻肺组织病变和ALI评分具有更强的活性。此外，EEP显著抑制肺内促炎介质的水平,包括TNF-α,IL-1β,IL-6和IFN-γ。肠道菌群分析显示，EEP和EEG都可以调节肠道菌群的组成，增强有益微生物群的丰度，减少有害微生物群，部分恢复短链脂肪酸的水平。EEP可以调节更多的血清代谢物，并且在血清代谢物和肠道微生物群之间显示出更强的相关性。总的来说,这些结果支持蜂胶在ALI治疗中的抗炎作用，以及蜂胶质量控制的必要性。
