PDF(Pubmed)
Abstract：
Anorexia nervosa (AN) is a severe eating disorder that predominantly affects females and typically manifests during adolescence. There is increasing evidence that serum cytokine levels are altered in individuals with AN. Previous research has largely focused on adult patients, assuming a low-grade pro-inflammatory state. The serum levels of the cytokine tumour necrosis factor-alpha (TNF-α), interleukin (IL)-1β, IL-6 and IL-15, which are pro-inflammatory, were examined in 63 female adolescents with AN and 41 age-matched healthy controls (HC). We included three time points (admission, discharge, and 1-year follow-up) and investigated the clinical data to assess whether the gut microbiota was associated with cytokine alterations. Relative to the HC group, serum levels of IL-1β and IL-6 were significantly lower during the acute phase (admission) of AN. IL-1β expression was normalised to control levels after weight recovery. TNF-α levels were not significantly different between the AN and HC groups. IL-15 levels were significantly elevated in patients with AN at all time points. We found associations between cytokines and bodyweight, illness duration, depressive symptoms, and the microbiome. In contrast to most findings for adults, we observed lower levels of the pro-inflammatory cytokines IL-1β and IL-6 in adolescent patients, whereas the level of IL-15 was consistently increased. Thus, the presence of inflammatory dysregulation suggests a varied rather than uniform pro-inflammatory state.
摘要：
神经性厌食症（AN）是一种严重的饮食失调，主要影响女性，通常在青春期出现。越来越多的证据表明，在患有AN的个体中，血清细胞因子水平会发生变化。以前的研究主要集中在成年患者身上，假设为低度促炎状态。细胞因子肿瘤坏死因子-α（TNF-α）的血清水平，白细胞介素（IL）-1β，IL-6和IL-15是促炎的，在63名患有AN的女性青少年和41名年龄匹配的健康对照（HC）中进行了检查。我们包括三个时间点(入院，放电,和1年随访），并调查了临床数据以评估肠道微生物群是否与细胞因子改变有关。相对于HC组，在AN急性期（入院），血清IL-1β和IL-6水平显着降低。在体重恢复后,将IL-1β表达标准化至对照水平。TNF-α水平在AN和HC组之间没有显着差异。在所有时间点，AN患者的IL-15水平均显着升高。我们发现细胞因子和体重之间有关联,疾病持续时间,抑郁症状,和微生物组。与大多数成年人的发现相反，我们观察到青少年患者的促炎细胞因子IL-1β和IL-6水平较低，而IL-15水平持续升高。因此，炎症失调的存在提示不同而非一致的促炎状态.
