PDF(Pubmed)
Abstract：
South Africa is the epicentre of the global HIV pandemic, with 13.9% of its population infected. Preeclampsia (PE), a hypertensive disorder of pregnancy, is often comorbid with HIV infection, leading to multi-organ dysfunction and convulsions. The exact pathophysiology of preeclampsia is triggered by an altered maternal immune response or defective development of maternal tolerance to the semi-allogenic foetus via the complement system. The complement system plays a vital role in the innate immune system, generating inflammation, mediating the clearance of microbes and injured tissue materials, and a mediator of adaptive immunity. Moreover, the complement system has a dual effect, of protecting the host against HIV infection and enhancing HIV infectivity. An upregulation of regulatory proteins has been implicated as an adaptive phenomenon in response to elevated complement-mediated cell lysis in HIV infection, further aggravated by preeclamptic complement activation. In light of the high prevalence of HIV infection and preeclampsia in South Africa, this review discusses the association of complement proteins and their role in the synergy of HIV infection and preeclampsia in South Africa. It aims to identify women at elevated risk, leading to early diagnosis and better management with targeted drug therapy, thereby improving the understanding of immunological dysregulation.
摘要：
南非是全球艾滋病大流行的中心,13.9%的人口被感染。先兆子痫(PE),妊娠高血压疾病，经常与艾滋病毒感染共病，导致多器官功能障碍和抽搐。先兆子痫的确切病理生理学是由改变的母体免疫应答或通过补体系统对半同种异体胎儿的母体耐受性的缺陷发展引发的。补体系统在先天免疫系统中起着至关重要的作用,产生炎症，介导微生物和损伤组织材料的清除，和适应性免疫的中介。此外，补体系统具有双重作用，保护宿主免受HIV感染和增强HIV感染性。在HIV感染中，调节蛋白的上调被认为是响应补体介导的细胞裂解升高的适应性现象。先兆子痫补体激活进一步加重。鉴于南非艾滋病毒感染和先兆子痫的高患病率，这篇综述讨论了补体蛋白的关联及其在南非HIV感染和先兆子痫的协同作用中的作用。它旨在识别处于高风险的女性，导致早期诊断和更好的管理与靶向药物治疗，从而提高对免疫失调的认识。
