PDF(Pubmed)
Abstract：
The mammalian target of rapamycin (mTOR) is a pivotal regulator, integrating diverse environmental signals to control fundamental cellular functions, such as protein synthesis, cell growth, survival, and apoptosis. Embedded in a complex network of signaling pathways, mTOR dysregulation is implicated in the onset and progression of a range of human diseases, including metabolic disorders such as diabetes and cardiovascular diseases, as well as various cancers. mTOR also has a notable role in aging. Given its extensive biological impact, mTOR signaling is a prime therapeutic target for addressing these complex conditions. The development of mTOR inhibitors has proven advantageous in numerous research domains. This review delves into the significance of mTOR signaling, highlighting the critical components of this intricate network that contribute to disease. Additionally, it addresses the latest findings on mTOR inhibitors and their clinical implications. The review also emphasizes the importance of developing more effective next-generation mTOR inhibitors with dual functions to efficiently target the mTOR pathways. A comprehensive understanding of mTOR signaling will enable the development of effective therapeutic strategies for managing diseases associated with mTOR dysregulation.
摘要：
哺乳动物雷帕霉素靶蛋白(mTOR)是一个关键的调节因子,整合不同的环境信号来控制基本的细胞功能，如蛋白质合成，细胞生长,生存,和凋亡。嵌入在信号通路的复杂网络中，mTOR失调与一系列人类疾病的发生和进展有关，包括代谢紊乱，如糖尿病和心血管疾病，以及各种癌症。mTOR在衰老中也具有显著的作用。鉴于其广泛的生物学影响，mTOR信号传导是解决这些复杂病症的主要治疗靶标。mTOR抑制剂的开发已经证明在许多研究领域是有利的。这篇综述深入研究了mTOR信号的重要性，突出了导致疾病的这个复杂网络的关键组成部分。此外,它阐述了mTOR抑制剂的最新发现及其临床意义。该综述还强调了开发具有双重功能的更有效的下一代mTOR抑制剂以有效靶向mTOR途径的重要性。对mTOR信号传导的全面了解将能够开发用于管理与mTOR失调相关的疾病的有效治疗策略。
