PDF(Pubmed)
Abstract：
Cardiovascular complications are the most deadly and cost-driving effects of diabetes mellitus (DM). One of them, which is steadily attracting attention among scientists, is diabetes-induced heart failure, also known as diabetic cardiomyopathy (DCM). Despite significant progress in the research concerning the disease, a universally accepted definition is still lacking. The pathophysiology of the processes accelerating heart insufficiency in diabetic patients on molecular and cellular levels also remains elusive. However, the recent interest concerning extracellular vesicles (EVs) has brought promise to further clarifying the pathological events that lead to DCM. In this review, we sum up recent investigations on the involvement of EVs in DCM and show their therapeutic and indicatory potential.
摘要：
心血管并发症是糖尿病（DM）最致命和成本驱动的影响。其中一个,这正在稳步吸引科学家的注意力，是糖尿病引起的心力衰竭,也称为糖尿病心肌病（DCM）。尽管有关该疾病的研究取得了重大进展，仍然缺乏一个普遍接受的定义。在分子和细胞水平上加速糖尿病患者心功能不全的过程的病理生理学也仍然难以捉摸。然而,最近对细胞外囊泡（EV）的兴趣为进一步阐明导致DCM的病理事件带来了希望。在这次审查中,我们总结了最近对EV参与DCM的研究，并显示了其治疗和指示潜力。
